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- W2074584459 abstract "Abstract Deregulated cell division is a hallmark of cancer, but whether tumor cells become dependent on specific mitotic mechanisms is not known. Here, we show that the small GTPase Ran, a regulator of mitotic spindle formation, is differentially overexpressed in human cancer as compared with normal tissues, in vivo. Acute silencing of Ran in various tumor cell types causes aberrant mitotic spindle formation, mitochondrial dysfunction, and apoptosis. This pathway does not require p53, Bax, or Smac, but is controlled by survivin as a novel Ran target in cancer. Conversely, loss of Ran in normal cells is well tolerated and does not result in mitotic defects or loss of cell viability. Therefore, tumor cells can become dependent on Ran signaling for cell division, and targeting this pathway may provide a novel and selective anticancer strategy. [Cancer Res 2008;68(6):1826–33]" @default.
- W2074584459 created "2016-06-24" @default.
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- W2074584459 date "2008-03-13" @default.
- W2074584459 modified "2023-10-18" @default.
- W2074584459 title "Tumor Cell Dependence on Ran-GTP–Directed Mitosis" @default.
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- W2074584459 doi "https://doi.org/10.1158/0008-5472.can-07-5279" @default.
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