Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074586247> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2074586247 endingPage "95" @default.
- W2074586247 startingPage "85" @default.
- W2074586247 abstract "The difference between the development of physical dependence on morphine administered via Alzet miniosmotic pumps as well as syringe injection (twice a day) at fixed times was examined in conscious dogs. Physical dependence was quantified by polygraphically measuring naloxone-precipitated withdrawal signs on the day 8 after the subcutaneous implantation of miniosmotic pumps which supplied morphine at 1-5 mg/kg/day. Morphine plasma levels were maintained at 19-25 and 41-47 ng/mL during infusions of morphine at doses of 2.5 and 5 mg/kg/day, respectively. Morphine withdrawal was characterized by hyperactivity, biting, digging, tremors, nausea, hyperthermia, and increased wakefulness, and by electroencephalographic (EEG) activation in the amygdala and hippocampus, followed by dissociation of the EEG in the cortex (fast wave) from that in the limbic (slow wave) system, increased heart rates, and raised blood pressure. These morphine withdrawal signs seemed to be more severe than those exhibited in animals that had received syringe injections of morphine at the same doses. These results suggest that the use of miniosmotic pumps in dogs may be a very convenient and useful method for both evaluating drug dependence and studying its mechanisms." @default.
- W2074586247 created "2016-06-24" @default.
- W2074586247 creator A5033742350 @default.
- W2074586247 creator A5033804823 @default.
- W2074586247 creator A5039880423 @default.
- W2074586247 creator A5042258880 @default.
- W2074586247 date "1993-10-01" @default.
- W2074586247 modified "2023-10-03" @default.
- W2074586247 title "Physical dependence on morphine induced in dogs via the use of miniosmotic pumps" @default.
- W2074586247 cites W1971228342 @default.
- W2074586247 cites W2013679934 @default.
- W2074586247 cites W2044455434 @default.
- W2074586247 cites W2054514234 @default.
- W2074586247 cites W2065548294 @default.
- W2074586247 cites W2080843499 @default.
- W2074586247 cites W2112327125 @default.
- W2074586247 cites W2549438840 @default.
- W2074586247 cites W4247789584 @default.
- W2074586247 doi "https://doi.org/10.1016/1056-8719(93)90011-3" @default.
- W2074586247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8298185" @default.
- W2074586247 hasPublicationYear "1993" @default.
- W2074586247 type Work @default.
- W2074586247 sameAs 2074586247 @default.
- W2074586247 citedByCount "15" @default.
- W2074586247 countsByYear W20745862472013 @default.
- W2074586247 countsByYear W20745862472014 @default.
- W2074586247 countsByYear W20745862472017 @default.
- W2074586247 crossrefType "journal-article" @default.
- W2074586247 hasAuthorship W2074586247A5033742350 @default.
- W2074586247 hasAuthorship W2074586247A5033804823 @default.
- W2074586247 hasAuthorship W2074586247A5039880423 @default.
- W2074586247 hasAuthorship W2074586247A5042258880 @default.
- W2074586247 hasConcept C15744967 @default.
- W2074586247 hasConcept C2777389121 @default.
- W2074586247 hasConcept C2778195246 @default.
- W2074586247 hasConcept C42219234 @default.
- W2074586247 hasConcept C71924100 @default.
- W2074586247 hasConceptScore W2074586247C15744967 @default.
- W2074586247 hasConceptScore W2074586247C2777389121 @default.
- W2074586247 hasConceptScore W2074586247C2778195246 @default.
- W2074586247 hasConceptScore W2074586247C42219234 @default.
- W2074586247 hasConceptScore W2074586247C71924100 @default.
- W2074586247 hasIssue "2" @default.
- W2074586247 hasLocation W20745862471 @default.
- W2074586247 hasLocation W20745862472 @default.
- W2074586247 hasOpenAccess W2074586247 @default.
- W2074586247 hasPrimaryLocation W20745862471 @default.
- W2074586247 hasRelatedWork W1207237070 @default.
- W2074586247 hasRelatedWork W1487700558 @default.
- W2074586247 hasRelatedWork W2000041866 @default.
- W2074586247 hasRelatedWork W2007302558 @default.
- W2074586247 hasRelatedWork W2060367792 @default.
- W2074586247 hasRelatedWork W2097088407 @default.
- W2074586247 hasRelatedWork W2143590269 @default.
- W2074586247 hasRelatedWork W2748952813 @default.
- W2074586247 hasRelatedWork W2899084033 @default.
- W2074586247 hasRelatedWork W2064048453 @default.
- W2074586247 hasVolume "30" @default.
- W2074586247 isParatext "false" @default.
- W2074586247 isRetracted "false" @default.
- W2074586247 magId "2074586247" @default.
- W2074586247 workType "article" @default.