Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074586719> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2074586719 endingPage "846" @default.
- W2074586719 startingPage "840" @default.
- W2074586719 abstract "The low-affinity receptor for immunoglobulin G, FcγRIIB, is expressed on most B-cells and on immature and activated mature T-cells. Co-aggregation of FcγRIIB with the B-cell antigen receptor (BCR) leads to attenuation of BCR-induced blastogenesis and cell proliferation via inhibition of p21ras, phosphatidylinositol 3-kinase (PI3-K) and phospholipase Cγ (PLCγ) activation. These effects are mediated, at least in part, by the recruitment of SH2-containing protein tyrosine phosphatase-1 (SHP-1) and -2 (SHP-2) and SH2-containing inositol 5-phosphatase(SHIP). In this report, we demonstrate that FcγRIIB co-aggregation with the T-cell antigen receptor (TCR), which may occur when T-cells recognize antibody-coated target cells, leads to inhibition of TCR-induced phosphorylation of the linker of activated T-cells (LAT). When phosphorylated, LAT functions as an adapter molecule and recruits PI3-K. Additionally, we demonstrate that PI3-K is required for TCR-induced Ca2+ mobilization. Together, these data suggest that FcγRIIB may inhibit TCR-mediated Ca2+ mobilization, in part via inhibition of LAT phosphorylation and subsequent inhibition of PI3-K activation. A similar mechanism has been described in B-cells, where FcγRIIB co-aggregation with the BCR leads to inhibition of PI3-K activity via dephosphorylation of CD19. It is likely that, in both cell types, levels of PtdIns(3,4,5)P3 are additionally modulated via the enzymic activity of SHIP." @default.
- W2074586719 created "2016-06-24" @default.
- W2074586719 creator A5014862292 @default.
- W2074586719 creator A5053755745 @default.
- W2074586719 creator A5056177877 @default.
- W2074586719 creator A5063233755 @default.
- W2074586719 date "2001-11-01" @default.
- W2074586719 modified "2023-10-15" @default.
- W2074586719 title "FcγRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization" @default.
- W2074586719 doi "https://doi.org/10.1042/bst0290840" @default.
- W2074586719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11709085" @default.
- W2074586719 hasPublicationYear "2001" @default.
- W2074586719 type Work @default.
- W2074586719 sameAs 2074586719 @default.
- W2074586719 citedByCount "18" @default.
- W2074586719 countsByYear W20745867192015 @default.
- W2074586719 countsByYear W20745867192016 @default.
- W2074586719 countsByYear W20745867192018 @default.
- W2074586719 crossrefType "journal-article" @default.
- W2074586719 hasAuthorship W2074586719A5014862292 @default.
- W2074586719 hasAuthorship W2074586719A5053755745 @default.
- W2074586719 hasAuthorship W2074586719A5056177877 @default.
- W2074586719 hasAuthorship W2074586719A5063233755 @default.
- W2074586719 hasConcept C11960822 @default.
- W2074586719 hasConcept C153911025 @default.
- W2074586719 hasConcept C170493617 @default.
- W2074586719 hasConcept C178666793 @default.
- W2074586719 hasConcept C181912034 @default.
- W2074586719 hasConcept C184235292 @default.
- W2074586719 hasConcept C185592680 @default.
- W2074586719 hasConcept C19317047 @default.
- W2074586719 hasConcept C203014093 @default.
- W2074586719 hasConcept C2776090121 @default.
- W2074586719 hasConcept C2777553839 @default.
- W2074586719 hasConcept C35174551 @default.
- W2074586719 hasConcept C42362537 @default.
- W2074586719 hasConcept C55493867 @default.
- W2074586719 hasConcept C62478195 @default.
- W2074586719 hasConcept C85528070 @default.
- W2074586719 hasConcept C86803240 @default.
- W2074586719 hasConcept C8891405 @default.
- W2074586719 hasConcept C95444343 @default.
- W2074586719 hasConceptScore W2074586719C11960822 @default.
- W2074586719 hasConceptScore W2074586719C153911025 @default.
- W2074586719 hasConceptScore W2074586719C170493617 @default.
- W2074586719 hasConceptScore W2074586719C178666793 @default.
- W2074586719 hasConceptScore W2074586719C181912034 @default.
- W2074586719 hasConceptScore W2074586719C184235292 @default.
- W2074586719 hasConceptScore W2074586719C185592680 @default.
- W2074586719 hasConceptScore W2074586719C19317047 @default.
- W2074586719 hasConceptScore W2074586719C203014093 @default.
- W2074586719 hasConceptScore W2074586719C2776090121 @default.
- W2074586719 hasConceptScore W2074586719C2777553839 @default.
- W2074586719 hasConceptScore W2074586719C35174551 @default.
- W2074586719 hasConceptScore W2074586719C42362537 @default.
- W2074586719 hasConceptScore W2074586719C55493867 @default.
- W2074586719 hasConceptScore W2074586719C62478195 @default.
- W2074586719 hasConceptScore W2074586719C85528070 @default.
- W2074586719 hasConceptScore W2074586719C86803240 @default.
- W2074586719 hasConceptScore W2074586719C8891405 @default.
- W2074586719 hasConceptScore W2074586719C95444343 @default.
- W2074586719 hasIssue "6" @default.
- W2074586719 hasLocation W20745867191 @default.
- W2074586719 hasOpenAccess W2074586719 @default.
- W2074586719 hasPrimaryLocation W20745867191 @default.
- W2074586719 hasRelatedWork W1534090153 @default.
- W2074586719 hasRelatedWork W1580168755 @default.
- W2074586719 hasRelatedWork W2027995286 @default.
- W2074586719 hasRelatedWork W2035962909 @default.
- W2074586719 hasRelatedWork W2059663039 @default.
- W2074586719 hasRelatedWork W2064460444 @default.
- W2074586719 hasRelatedWork W2068747852 @default.
- W2074586719 hasRelatedWork W2094162913 @default.
- W2074586719 hasRelatedWork W2103457718 @default.
- W2074586719 hasRelatedWork W2183062661 @default.
- W2074586719 hasVolume "29" @default.
- W2074586719 isParatext "false" @default.
- W2074586719 isRetracted "false" @default.
- W2074586719 magId "2074586719" @default.
- W2074586719 workType "article" @default.