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- W2074591330 endingPage "1076" @default.
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- W2074591330 abstract "Transplantation therapies have revolutionized care for patients with endstage organ (kidney, liver, heart, lung, and pancreatic beta-cell) failure, yet significant problems persist with treatments designed to prevent graft rejection. Antirejection therapies are not always effective, must be taken daily, and are both expensive and associated with well-known toxic effects. Recent advances have suggested that the immune system has more self-regulatory capability than previously appreciated. In this review, we discuss immune system function and new therapeutic agents that modify so-called costimulatory receptor signaling to support transplant function without generally suppressing the immune system." @default.
- W2074591330 created "2016-06-24" @default.
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- W2074591330 date "1999-09-15" @default.
- W2074591330 modified "2023-10-18" @default.
- W2074591330 title "The Future of Organ and Tissue Transplantation" @default.
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- W2074591330 doi "https://doi.org/10.1001/jama.282.11.1076" @default.
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