Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074593863> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2074593863 endingPage "2144" @default.
- W2074593863 startingPage "2137" @default.
- W2074593863 abstract "Further structure-activity relationships (SAR) for a novel dipeptide series inhibitors are reported. These inhibitors retain the Phe8-His9 portion of angiotensinogen and employ a unique Leu10-Val11 replacement [(LVR), ref 2]. SAR at the Leu10 side chain revealed that the LVR derived from cyclohexylalanine provided a nearly 10-fold boost in potency for the final inhibitor. In addition SAR work was carried out to delineate the relationships between binding potency and (1) the size, shape, and charge of the side chain at the His9 position; (2) the size and topology of the side chain at the Phe8 site; and (3) the size of the Phe8 N-protecting group. One of the more potent inhibitors, 12, was shown to provide a substantial antihypertensive effect in a sodium depleted monkey model when administered intravenously. Metabolism work, in Sprague-Dawley rats, provided insights into the susceptibility of 12 to significant hepatic clearance and provided encouraging evidence for intestinal absorption." @default.
- W2074593863 created "2016-06-24" @default.
- W2074593863 creator A5006562450 @default.
- W2074593863 creator A5015521215 @default.
- W2074593863 creator A5035909731 @default.
- W2074593863 creator A5038023856 @default.
- W2074593863 creator A5051877114 @default.
- W2074593863 creator A5059678115 @default.
- W2074593863 creator A5068677359 @default.
- W2074593863 creator A5089200254 @default.
- W2074593863 creator A5020137642 @default.
- W2074593863 date "1987-11-01" @default.
- W2074593863 modified "2023-09-26" @default.
- W2074593863 title "Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement" @default.
- W2074593863 doi "https://doi.org/10.1021/jm00394a035" @default.
- W2074593863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3118024" @default.
- W2074593863 hasPublicationYear "1987" @default.
- W2074593863 type Work @default.
- W2074593863 sameAs 2074593863 @default.
- W2074593863 citedByCount "32" @default.
- W2074593863 crossrefType "journal-article" @default.
- W2074593863 hasAuthorship W2074593863A5006562450 @default.
- W2074593863 hasAuthorship W2074593863A5015521215 @default.
- W2074593863 hasAuthorship W2074593863A5020137642 @default.
- W2074593863 hasAuthorship W2074593863A5035909731 @default.
- W2074593863 hasAuthorship W2074593863A5038023856 @default.
- W2074593863 hasAuthorship W2074593863A5051877114 @default.
- W2074593863 hasAuthorship W2074593863A5059678115 @default.
- W2074593863 hasAuthorship W2074593863A5068677359 @default.
- W2074593863 hasAuthorship W2074593863A5089200254 @default.
- W2074593863 hasConcept C150903083 @default.
- W2074593863 hasConcept C178790620 @default.
- W2074593863 hasConcept C185592680 @default.
- W2074593863 hasConcept C193042331 @default.
- W2074593863 hasConcept C202751555 @default.
- W2074593863 hasConcept C204921945 @default.
- W2074593863 hasConcept C207001950 @default.
- W2074593863 hasConcept C2779138802 @default.
- W2074593863 hasConcept C2779281246 @default.
- W2074593863 hasConcept C521977710 @default.
- W2074593863 hasConcept C55493867 @default.
- W2074593863 hasConcept C57992300 @default.
- W2074593863 hasConcept C71240020 @default.
- W2074593863 hasConcept C71924100 @default.
- W2074593863 hasConcept C86803240 @default.
- W2074593863 hasConcept C98274493 @default.
- W2074593863 hasConceptScore W2074593863C150903083 @default.
- W2074593863 hasConceptScore W2074593863C178790620 @default.
- W2074593863 hasConceptScore W2074593863C185592680 @default.
- W2074593863 hasConceptScore W2074593863C193042331 @default.
- W2074593863 hasConceptScore W2074593863C202751555 @default.
- W2074593863 hasConceptScore W2074593863C204921945 @default.
- W2074593863 hasConceptScore W2074593863C207001950 @default.
- W2074593863 hasConceptScore W2074593863C2779138802 @default.
- W2074593863 hasConceptScore W2074593863C2779281246 @default.
- W2074593863 hasConceptScore W2074593863C521977710 @default.
- W2074593863 hasConceptScore W2074593863C55493867 @default.
- W2074593863 hasConceptScore W2074593863C57992300 @default.
- W2074593863 hasConceptScore W2074593863C71240020 @default.
- W2074593863 hasConceptScore W2074593863C71924100 @default.
- W2074593863 hasConceptScore W2074593863C86803240 @default.
- W2074593863 hasConceptScore W2074593863C98274493 @default.
- W2074593863 hasIssue "11" @default.
- W2074593863 hasLocation W20745938631 @default.
- W2074593863 hasLocation W20745938632 @default.
- W2074593863 hasOpenAccess W2074593863 @default.
- W2074593863 hasPrimaryLocation W20745938631 @default.
- W2074593863 hasRelatedWork W1997949901 @default.
- W2074593863 hasRelatedWork W2019700826 @default.
- W2074593863 hasRelatedWork W2067960249 @default.
- W2074593863 hasRelatedWork W2119697230 @default.
- W2074593863 hasRelatedWork W2134417758 @default.
- W2074593863 hasRelatedWork W2145306431 @default.
- W2074593863 hasRelatedWork W2396932951 @default.
- W2074593863 hasRelatedWork W2800648910 @default.
- W2074593863 hasRelatedWork W2951575765 @default.
- W2074593863 hasRelatedWork W2953758866 @default.
- W2074593863 hasVolume "30" @default.
- W2074593863 isParatext "false" @default.
- W2074593863 isRetracted "false" @default.
- W2074593863 magId "2074593863" @default.
- W2074593863 workType "article" @default.