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• W2074594917 abstract "Pleomorphic adenoma (PA), also known as mixed tumor, is the most common benign salivary gland neoplasm, characterized histologically by both epithelial and mesenchymal elements. 1 Neville B.W. Damm D.D. Allen C.M. et al. Oral and Maxillofacial Pathology. in: (ed 3). WB Saunders, St. Louis, MO2009: 493 Google Scholar Approximately 75% of PAs occur in the parotid gland, followed by the submandibular gland (15%) and minor glands of the palate and nasal septum (10%). 2 Manucha V. Ioffe O.B. Metastasizing pleomorphic adenoma of the salivary gland. Arch Pathol Lab Med. 2008; 132: 1445 PubMed Google Scholar Less common is the occurrence in the minor glands of the upper lip, cheek, floor of mouth, larynx, and trachea. 3 Bae C.H. Yong-Dae D. Song S.Y. Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus. Clin Exp Otorhinolaryngol. 2010; 3: 172 Crossref PubMed Scopus (21) Google Scholar Malignant mixed tumors encompassing the entities, carcinoma ex pleomorphic adenoma, carcinosarcoma, or metastatic pleomorphic adenoma (MPA), are rare and represent 2% to 6% of all salivary gland tumors. 1 Neville B.W. Damm D.D. Allen C.M. et al. Oral and Maxillofacial Pathology. in: (ed 3). WB Saunders, St. Louis, MO2009: 493 Google Scholar MPA is the least common subtype of malignant mixed tumors. 1 Neville B.W. Damm D.D. Allen C.M. et al. Oral and Maxillofacial Pathology. in: (ed 3). WB Saunders, St. Louis, MO2009: 493 Google Scholar By definition, the histologic features of MPA must be identical to those of the PA of the initial salivary gland site. The sites of MPA are similar to the anatomic metastatic sites of other malignant salivary gland tumors, 2 Manucha V. Ioffe O.B. Metastasizing pleomorphic adenoma of the salivary gland. Arch Pathol Lab Med. 2008; 132: 1445 PubMed Google Scholar , 4 Klijanienko J. El-Naggar A.K. Servois V. et al. Clinically aggressive metastasizing pleomorphic adenoma: Report of two cases. Head Neck. 1997; 19: 629 Crossref PubMed Scopus (38) Google Scholar and hematogenous spread of MPA is more common than lymphatic. 5 Skarin A. China C. Masaki K.H. et al. Unusual presentations of uncommon tumors: Case 1. Benign metastasizing pleomorphic adenoma. J Clin Oncol. 2002; 20: 2400 PubMed Google Scholar Bone is the most common metastatic location for MPAs (45%), followed by the head and neck (43%), lung (36%), and, less often, lymph nodes, paranasal sinuses, the central nervous system, kidneys, liver, or skin. 3 Bae C.H. Yong-Dae D. Song S.Y. Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus. Clin Exp Otorhinolaryngol. 2010; 3: 172 Crossref PubMed Scopus (21) Google Scholar , 6 Wenig B.M. Hitchcock C.L. Ellis G.L. et al. Metastasizing mixed tumor of salivary glands: A clinicopathologic and flow cytometric analysis. Am J Surg Pathol. 1992; 16: 845 Crossref PubMed Scopus (111) Google Scholar , 7 Nouraei S.A. Ferguson M.S. Clarke P.M. et al. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg. 2006; 132: 788 Crossref PubMed Scopus (62) Google Scholar We report the first, to our knowledge, example of MPA with alveolar bone metastasis." @default.
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• W2074594917 date "2012-10-01" @default.
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• W2074594917 title "Metastasizing Pleomorphic Adenoma Presents Intraorally: A Case Report and Review of the Literature" @default.
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• W2074594917 doi "https://doi.org/10.1016/j.joms.2012.06.185" @default.
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