FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074610410> ?p ?o ?g. }

• W2074610410 endingPage "1622" @default.
• W2074610410 startingPage "1617" @default.
• W2074610410 abstract "The objective of this study was to evaluate the in vivo secretion profile of ciliary neurotrophic factor (CNTF) from either of two genetically engineered cell lines contained in the encapsulated cell therapy (ECT)-based NT-501 device. ECT devices were loaded with either a low or high CNTF-secreting cell line and implanted into rabbit eyes for 1, 3, 7, 14, 30, 60, 90, 135, 180, or 365 days. After explantation, the vitreous was sampled and devices were allowed to incubate in endothelial serum-free medium for 24 h at 37 degrees C. Both the vitreous and the conditioned medium were assayed for CNTF using an ELISA. Device and vitreous CNTF, were plotted against time, and regression analysis was used to calculate half-life. Devices loaded with either cell line showed stable in vivo output for the duration of the study, with populations of healthy cells remaining in the device at study termination. For the low-dose CNTF-secreting cell line, with the final time point at 6 months, the halflife was estimated as 71 days, whereas the high-dose devices, with a final time point of 1 year, had an associated half-life of approximately 198 days. The NT-501 device is capable of delivering CNTF to the vitreous for at least 1 year. This ECT-based device, which has been shown to be safe and effective by our group, is a well-engineered ECT-based controlled delivery system capable of protein output on the order of years." @default.
• W2074610410 created "2016-06-24" @default.
• W2074610410 creator A5004657012 @default.
• W2074610410 creator A5016331919 @default.
• W2074610410 creator A5024761740 @default.
• W2074610410 creator A5031378038 @default.
• W2074610410 creator A5035094174 @default.
• W2074610410 creator A5066049217 @default.
• W2074610410 creator A5073779207 @default.
• W2074610410 date "2004-11-01" @default.
• W2074610410 modified "2023-10-01" @default.
• W2074610410 title "Sustained Secretion of Ciliary Neurotrophic Factor to the Vitreous, Using the Encapsulated Cell Therapy-Based NT-501 Intraocular Device" @default.
• W2074610410 cites W1780664938 @default.
• W2074610410 cites W1845093339 @default.
• W2074610410 cites W1983378672 @default.
• W2074610410 cites W2014855145 @default.
• W2074610410 cites W2041839984 @default.
• W2074610410 cites W2058075639 @default.
• W2074610410 cites W2079764967 @default.
• W2074610410 cites W2142761289 @default.
• W2074610410 cites W2328355715 @default.
• W2074610410 doi "https://doi.org/10.1089/ten.2004.10.1617" @default.
• W2074610410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15684670" @default.
• W2074610410 hasPublicationYear "2004" @default.
• W2074610410 type Work @default.
• W2074610410 sameAs 2074610410 @default.
• W2074610410 citedByCount "75" @default.
• W2074610410 countsByYear W20746104102012 @default.
• W2074610410 countsByYear W20746104102013 @default.
• W2074610410 countsByYear W20746104102014 @default.
• W2074610410 countsByYear W20746104102015 @default.
• W2074610410 countsByYear W20746104102016 @default.
• W2074610410 countsByYear W20746104102017 @default.
• W2074610410 countsByYear W20746104102018 @default.
• W2074610410 countsByYear W20746104102019 @default.
• W2074610410 countsByYear W20746104102020 @default.
• W2074610410 countsByYear W20746104102021 @default.
• W2074610410 countsByYear W20746104102022 @default.
• W2074610410 countsByYear W20746104102023 @default.
• W2074610410 crossrefType "journal-article" @default.
• W2074610410 hasAuthorship W2074610410A5004657012 @default.
• W2074610410 hasAuthorship W2074610410A5016331919 @default.
• W2074610410 hasAuthorship W2074610410A5024761740 @default.
• W2074610410 hasAuthorship W2074610410A5031378038 @default.
• W2074610410 hasAuthorship W2074610410A5035094174 @default.
• W2074610410 hasAuthorship W2074610410A5066049217 @default.
• W2074610410 hasAuthorship W2074610410A5073779207 @default.
• W2074610410 hasConcept C118487528 @default.
• W2074610410 hasConcept C126322002 @default.
• W2074610410 hasConcept C136229726 @default.
• W2074610410 hasConcept C1491633281 @default.
• W2074610410 hasConcept C150903083 @default.
• W2074610410 hasConcept C160539049 @default.
• W2074610410 hasConcept C170493617 @default.
• W2074610410 hasConcept C185592680 @default.
• W2074610410 hasConcept C207001950 @default.
• W2074610410 hasConcept C49039625 @default.
• W2074610410 hasConcept C54355233 @default.
• W2074610410 hasConcept C55493867 @default.
• W2074610410 hasConcept C68710172 @default.
• W2074610410 hasConcept C71924100 @default.
• W2074610410 hasConcept C81885089 @default.
• W2074610410 hasConcept C86803240 @default.
• W2074610410 hasConceptScore W2074610410C118487528 @default.
• W2074610410 hasConceptScore W2074610410C126322002 @default.
• W2074610410 hasConceptScore W2074610410C136229726 @default.
• W2074610410 hasConceptScore W2074610410C1491633281 @default.
• W2074610410 hasConceptScore W2074610410C150903083 @default.
• W2074610410 hasConceptScore W2074610410C160539049 @default.
• W2074610410 hasConceptScore W2074610410C170493617 @default.
• W2074610410 hasConceptScore W2074610410C185592680 @default.
• W2074610410 hasConceptScore W2074610410C207001950 @default.
• W2074610410 hasConceptScore W2074610410C49039625 @default.
• W2074610410 hasConceptScore W2074610410C54355233 @default.
• W2074610410 hasConceptScore W2074610410C55493867 @default.
• W2074610410 hasConceptScore W2074610410C68710172 @default.
• W2074610410 hasConceptScore W2074610410C71924100 @default.
• W2074610410 hasConceptScore W2074610410C81885089 @default.
• W2074610410 hasConceptScore W2074610410C86803240 @default.
• W2074610410 hasIssue "11-12" @default.
• W2074610410 hasLocation W20746104101 @default.
• W2074610410 hasLocation W20746104102 @default.
• W2074610410 hasOpenAccess W2074610410 @default.
• W2074610410 hasPrimaryLocation W20746104101 @default.
• W2074610410 hasRelatedWork W1119978864 @default.
• W2074610410 hasRelatedWork W1151325438 @default.
• W2074610410 hasRelatedWork W1503486271 @default.
• W2074610410 hasRelatedWork W204859981 @default.
• W2074610410 hasRelatedWork W2090332283 @default.
• W2074610410 hasRelatedWork W2120643414 @default.
• W2074610410 hasRelatedWork W218266327 @default.
• W2074610410 hasRelatedWork W2317070312 @default.
• W2074610410 hasRelatedWork W2386833375 @default.
• W2074610410 hasRelatedWork W3177019421 @default.
• W2074610410 hasVolume "10" @default.
• W2074610410 isParatext "false" @default.
• W2074610410 isRetracted "false" @default.
• W2074610410 magId "2074610410" @default.

• next