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• W2074615902 abstract "► Furin is increased in the endometrium with increasing grades of endometrial cancer. ► PC5/6, PACE4 and PC7 are decreased in the endometrium with increasing cancer grades. ► PC activity in uterine lavage is significantly elevated with endometrial cancer. ► Measuring PC activity in uterine lavage may help to detect endometrial cancer. Proprotein convertases (PCs) play critical roles in cleaving precursor proteins (growth factors, hormones, receptors and adhesion molecules) for activation. PCs are implicated in a number of cellular functions, including oncogenesis. Endometrial cancer is the most common gynecological cancer in the developed world, but the involvement of PCs is unclear. To characterize the role of PCs in endometrial cancer, we assessed expression of seven PCs (PC1/3, PC2, PACE4, PC4, furin, PC5/6 and PC7) by RT-PCR in six well characterized endometrial cancer cell lines. Expression was variable in all lines, with furin being most consistently expressed in all cell lines tested. We next determined the cellular localization and expression levels of four ubiquitously expressed PCs (furin, PACE4, PC5/6 and PC7) in post-menopausal endometrial biopsies from control ( n = 7) and endometrial cancer patients ( n = 30) by immunohistochemistry. Furin increased in tumors, whereas PC5/6, PACE4 and PC7 expression was reduced with increasing cancer grades. Uterine lavage is a non-invasive source material for evaluating the endometrium. We thus assessed whether total PC activity was altered in uterine lavage of endometrial cancer patients ( n = 36) compared to controls ( n = 10). PC activity was detected in all uterine lavage samples, and significantly elevated in all grades of endometrial cancer. This study demonstrates a complex association between individual PCs and endometrial cancer. Importantly, we show that monitoring the total PC activity in uterine lavage may provide a rapid and non-invasive method for the diagnosis of endometrial cancer in postmenopausal women." @default.
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• W2074615902 date "2012-03-01" @default.
• W2074615902 modified "2023-09-27" @default.
• W2074615902 title "Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis" @default.
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• W2074615902 doi "https://doi.org/10.1016/j.bbrc.2012.02.111" @default.
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