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- W2074619197 abstract "The integrins are a family of cell surface receptors that mediate biologically important adhesive interactions. Integrin-ligand binding has been extensively studied because of the potential for the development of anti-adhesive therapies, but the molecular basis of this interaction is still poorly understood. A conserved region near the N-terminus of the β subunit appears to be of particular importance in ligand binding, but to date this domain has not been expressed in isolation. As a prelude to expression and potential structure determination, we have performed a detailed structure prediction for this region. Primary, secondary and tertiary structure analyses indicate that the region folds into a von Willebrand factor A-domain, thereby potentially placing a previously characterised module at the centre of a key functional region." @default.
- W2074619197 created "2016-06-24" @default.
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- W2074619197 date "1997-01-06" @default.
- W2074619197 modified "2023-09-27" @default.
- W2074619197 title "A structure prediction for the ligand-binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain" @default.
- W2074619197 cites W2001493281 @default.
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- W2074619197 doi "https://doi.org/10.1016/s0014-5793(96)01368-3" @default.
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