Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074632656> ?p ?o ?g. }
- W2074632656 endingPage "20069" @default.
- W2074632656 startingPage "20061" @default.
- W2074632656 abstract "Formins assemble non-branched actin filaments and modulate microtubule dynamics during cell migration and cell division. At the end of mitosis formins contribute to the generation of actin filaments that form the contractile ring. Rho small GTP-binding proteins activate mammalian diaphanous-related (mDia) formins by directly binding and disrupting an intramolecular autoinhibitory mechanism. Although the Rho-regulated activation mechanism is well characterized, little is known about how formins are switched off. Here we reveal a novel mechanism of formin regulation during cytokinesis based on the following observations; 1) mDia2 is degraded at the end of mitosis, 2) mDia2 is targeted for disposal by post-translational ubiquitin modification, 3) forced expression of activated mDia2 yields binucleate cells due to failed cytokinesis, and 4) the cytokinesis block is dependent upon mDia2-mediated actin assembly as versions of mDia2 incapable of nucleating actin but that still stabilize microtubules have no effect on cytokinesis. We propose that the tight control of mDia2 expression and ubiquitin-mediated degradation is essential for the completion of cell division. Because of the many roles for formins in cell morphology, we discuss the relevance of mDia protein turnover in other processes where ubiquitin-mediated proteolysis is an essential component." @default.
- W2074632656 created "2016-06-24" @default.
- W2074632656 creator A5005294767 @default.
- W2074632656 creator A5023869395 @default.
- W2074632656 date "2009-07-01" @default.
- W2074632656 modified "2023-10-09" @default.
- W2074632656 title "Ubiquitin-mediated Degradation of the Formin mDia2 upon Completion of Cell Division" @default.
- W2074632656 cites W1523601423 @default.
- W2074632656 cites W1969236463 @default.
- W2074632656 cites W1969761431 @default.
- W2074632656 cites W1974471014 @default.
- W2074632656 cites W1975287998 @default.
- W2074632656 cites W1979145729 @default.
- W2074632656 cites W1984332521 @default.
- W2074632656 cites W1984575308 @default.
- W2074632656 cites W1990356394 @default.
- W2074632656 cites W1990565440 @default.
- W2074632656 cites W1995151687 @default.
- W2074632656 cites W2008276517 @default.
- W2074632656 cites W2012212144 @default.
- W2074632656 cites W2016450222 @default.
- W2074632656 cites W2017214363 @default.
- W2074632656 cites W2026646663 @default.
- W2074632656 cites W2027866287 @default.
- W2074632656 cites W2029093937 @default.
- W2074632656 cites W2030768863 @default.
- W2074632656 cites W2036302388 @default.
- W2074632656 cites W2036856219 @default.
- W2074632656 cites W2045802318 @default.
- W2074632656 cites W2047853156 @default.
- W2074632656 cites W2049703426 @default.
- W2074632656 cites W2056889742 @default.
- W2074632656 cites W2057190824 @default.
- W2074632656 cites W2059746552 @default.
- W2074632656 cites W2060458509 @default.
- W2074632656 cites W2071869797 @default.
- W2074632656 cites W2076188917 @default.
- W2074632656 cites W2080375898 @default.
- W2074632656 cites W2094269474 @default.
- W2074632656 cites W2096358322 @default.
- W2074632656 cites W2102640342 @default.
- W2074632656 cites W2116344057 @default.
- W2074632656 cites W2122087650 @default.
- W2074632656 cites W2122257200 @default.
- W2074632656 cites W2127735672 @default.
- W2074632656 cites W2131407575 @default.
- W2074632656 cites W2133898534 @default.
- W2074632656 cites W2133987610 @default.
- W2074632656 cites W2136647702 @default.
- W2074632656 cites W2137240240 @default.
- W2074632656 cites W2139047645 @default.
- W2074632656 cites W2166244415 @default.
- W2074632656 cites W2168227282 @default.
- W2074632656 cites W4376848286 @default.
- W2074632656 cites W2560693326 @default.
- W2074632656 doi "https://doi.org/10.1074/jbc.m109.000885" @default.
- W2074632656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2740432" @default.
- W2074632656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19457867" @default.
- W2074632656 hasPublicationYear "2009" @default.
- W2074632656 type Work @default.
- W2074632656 sameAs 2074632656 @default.
- W2074632656 citedByCount "51" @default.
- W2074632656 countsByYear W20746326562012 @default.
- W2074632656 countsByYear W20746326562013 @default.
- W2074632656 countsByYear W20746326562014 @default.
- W2074632656 countsByYear W20746326562015 @default.
- W2074632656 countsByYear W20746326562016 @default.
- W2074632656 countsByYear W20746326562017 @default.
- W2074632656 countsByYear W20746326562018 @default.
- W2074632656 countsByYear W20746326562019 @default.
- W2074632656 countsByYear W20746326562020 @default.
- W2074632656 countsByYear W20746326562021 @default.
- W2074632656 countsByYear W20746326562022 @default.
- W2074632656 countsByYear W20746326562023 @default.
- W2074632656 crossrefType "journal-article" @default.
- W2074632656 hasAuthorship W2074632656A5005294767 @default.
- W2074632656 hasAuthorship W2074632656A5023869395 @default.
- W2074632656 hasBestOaLocation W20746326561 @default.
- W2074632656 hasConcept C104317684 @default.
- W2074632656 hasConcept C125705527 @default.
- W2074632656 hasConcept C142669718 @default.
- W2074632656 hasConcept C1491633281 @default.
- W2074632656 hasConcept C179411191 @default.
- W2074632656 hasConcept C185592680 @default.
- W2074632656 hasConcept C25602115 @default.
- W2074632656 hasConcept C2993400109 @default.
- W2074632656 hasConcept C45472230 @default.
- W2074632656 hasConcept C53195969 @default.
- W2074632656 hasConcept C55493867 @default.
- W2074632656 hasConcept C85813293 @default.
- W2074632656 hasConcept C86803240 @default.
- W2074632656 hasConcept C93304396 @default.
- W2074632656 hasConcept C95444343 @default.
- W2074632656 hasConceptScore W2074632656C104317684 @default.
- W2074632656 hasConceptScore W2074632656C125705527 @default.
- W2074632656 hasConceptScore W2074632656C142669718 @default.
- W2074632656 hasConceptScore W2074632656C1491633281 @default.
- W2074632656 hasConceptScore W2074632656C179411191 @default.