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• W2074632761 abstract "Regulatory T (Treg) cells are a developmentally and functionally distinct T cell subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis. The transcription factor Foxp3 plays a key role in Treg cell development and function. However, expression of Foxp3 alone is not sufficient for conferring and maintaining Treg cell function and phenotype. Complementing the insufficiency, Treg-cell-specific epigenetic changes are also critical in the process of Treg cell specification, in regulating its potential plasticity, and hence in establishing a stable lineage. Understanding how epigenetic alterations and Foxp3 expression coordinately control Treg-cell-specific gene regulation will enable better control of immune responses by targeting the generation and maintenance of Treg cells." @default.
• W2074632761 created "2016-06-24" @default.
• W2074632761 creator A5025764166 @default.
• W2074632761 creator A5030165999 @default.
• W2074632761 creator A5042599703 @default.
• W2074632761 date "2013-03-01" @default.
• W2074632761 modified "2023-10-17" @default.
• W2074632761 title "Development and Maintenance of Regulatory T cells" @default.
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• W2074632761 doi "https://doi.org/10.1016/j.immuni.2013.03.002" @default.
• W2074632761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23521883" @default.
• W2074632761 hasPublicationYear "2013" @default.
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