FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074634235> ?p ?o ?g. }

• W2074634235 endingPage "166" @default.
• W2074634235 startingPage "157" @default.
• W2074634235 abstract "Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is a 15 kDa regulatory protein packaged in the HIV-1 virion. Although the molecular mechanism of Vpr function during viral replication remains elusive, Vpr has been found to possess interesting biological activities, including cell-cycle arrest at the G2/M check point, promotion of the HIV-1 pre-integration complex for nuclear transport, and a low but significant level of transcriptional activation of a variety of viral and cellular promoters. We now present data suggesting that HIV-1 Vpr is a nucleic-acid-binding protein. This activity of Vpr was demonstrated by DNA-cellulose chromatography, antibody co-immunoprecipitation, and gel electrophoretic mobility shift assays. By mutational analysis, the C-terminal region of Vpr, which is rich in basic amino-acid residues, was shown to be critical for Vpr binding to nucleic acids. The nucleic-acid-binding activity of Vpr is consistent with several biological activities of Vpr and may provide an important clue for understanding the molecular interactions between HIV-1 and the host cells." @default.
• W2074634235 created "2016-06-24" @default.
• W2074634235 creator A5002772432 @default.
• W2074634235 creator A5009225924 @default.
• W2074634235 creator A5019252223 @default.
• W2074634235 creator A5024943139 @default.
• W2074634235 creator A5030260510 @default.
• W2074634235 creator A5089983770 @default.
• W2074634235 date "1998-06-01" @default.
• W2074634235 modified "2023-10-14" @default.
• W2074634235 title "Direct binding to nucleic acids by Vpr of human immunodeficiency virus type 1" @default.
• W2074634235 cites W1538467835 @default.
• W2074634235 cites W1557691749 @default.
• W2074634235 cites W1575318746 @default.
• W2074634235 cites W1585763437 @default.
• W2074634235 cites W1625926039 @default.
• W2074634235 cites W1683590180 @default.
• W2074634235 cites W1807747199 @default.
• W2074634235 cites W1913681141 @default.
• W2074634235 cites W1925504181 @default.
• W2074634235 cites W1942163038 @default.
• W2074634235 cites W1946734657 @default.
• W2074634235 cites W1955991880 @default.
• W2074634235 cites W1961313548 @default.
• W2074634235 cites W1979606611 @default.
• W2074634235 cites W1981206198 @default.
• W2074634235 cites W1981864966 @default.
• W2074634235 cites W1983747887 @default.
• W2074634235 cites W1991660519 @default.
• W2074634235 cites W1992602932 @default.
• W2074634235 cites W1997413979 @default.
• W2074634235 cites W2001243226 @default.
• W2074634235 cites W2007150582 @default.
• W2074634235 cites W2010840723 @default.
• W2074634235 cites W2048656467 @default.
• W2074634235 cites W2071246036 @default.
• W2074634235 cites W2077206910 @default.
• W2074634235 cites W2088598615 @default.
• W2074634235 cites W2088851522 @default.
• W2074634235 cites W2094023425 @default.
• W2074634235 cites W2098625990 @default.
• W2074634235 cites W2105944752 @default.
• W2074634235 cites W2107952852 @default.
• W2074634235 cites W2108779766 @default.
• W2074634235 cites W2122266844 @default.
• W2074634235 cites W2130200446 @default.
• W2074634235 cites W2132333091 @default.
• W2074634235 cites W2146187278 @default.
• W2074634235 cites W2150514496 @default.
• W2074634235 cites W2180229694 @default.
• W2074634235 cites W2226663394 @default.
• W2074634235 doi "https://doi.org/10.1016/s0378-1119(98)00178-4" @default.
• W2074634235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9611258" @default.
• W2074634235 hasPublicationYear "1998" @default.
• W2074634235 type Work @default.
• W2074634235 sameAs 2074634235 @default.
• W2074634235 citedByCount "51" @default.
• W2074634235 countsByYear W20746342352012 @default.
• W2074634235 countsByYear W20746342352013 @default.
• W2074634235 countsByYear W20746342352014 @default.
• W2074634235 countsByYear W20746342352015 @default.
• W2074634235 countsByYear W20746342352018 @default.
• W2074634235 countsByYear W20746342352020 @default.
• W2074634235 countsByYear W20746342352022 @default.
• W2074634235 crossrefType "journal-article" @default.
• W2074634235 hasAuthorship W2074634235A5002772432 @default.
• W2074634235 hasAuthorship W2074634235A5009225924 @default.
• W2074634235 hasAuthorship W2074634235A5019252223 @default.
• W2074634235 hasAuthorship W2074634235A5024943139 @default.
• W2074634235 hasAuthorship W2074634235A5030260510 @default.
• W2074634235 hasAuthorship W2074634235A5089983770 @default.
• W2074634235 hasConcept C104317684 @default.
• W2074634235 hasConcept C150194340 @default.
• W2074634235 hasConcept C153911025 @default.
• W2074634235 hasConcept C183978625 @default.
• W2074634235 hasConcept C24107716 @default.
• W2074634235 hasConcept C515207424 @default.
• W2074634235 hasConcept C552990157 @default.
• W2074634235 hasConcept C55493867 @default.
• W2074634235 hasConcept C71829478 @default.
• W2074634235 hasConcept C86339819 @default.
• W2074634235 hasConcept C86803240 @default.
• W2074634235 hasConcept C94966510 @default.
• W2074634235 hasConceptScore W2074634235C104317684 @default.
• W2074634235 hasConceptScore W2074634235C150194340 @default.
• W2074634235 hasConceptScore W2074634235C153911025 @default.
• W2074634235 hasConceptScore W2074634235C183978625 @default.
• W2074634235 hasConceptScore W2074634235C24107716 @default.
• W2074634235 hasConceptScore W2074634235C515207424 @default.
• W2074634235 hasConceptScore W2074634235C552990157 @default.
• W2074634235 hasConceptScore W2074634235C55493867 @default.
• W2074634235 hasConceptScore W2074634235C71829478 @default.
• W2074634235 hasConceptScore W2074634235C86339819 @default.
• W2074634235 hasConceptScore W2074634235C86803240 @default.
• W2074634235 hasConceptScore W2074634235C94966510 @default.
• W2074634235 hasIssue "2" @default.
• W2074634235 hasLocation W20746342351 @default.
• W2074634235 hasLocation W20746342352 @default.

• next