FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074648081> ?p ?o ?g. }

• W2074648081 endingPage "110" @default.
• W2074648081 startingPage "100" @default.
• W2074648081 abstract "Large-scale hemizygous loss of chromosome 3p is a common event in neuroblastoma, occurring preferentially in tumors that exhibit loss of chromosome 11q and lack MYCN amplification. Although numerous tumor suppressor genes (TSG) have been mapped to the 3p region, the gene or genes contributing to neuroblastoma pathogenesis have remained elusive. High-resolution oligonucleotide array CGH mapping of chromosome 3p breakpoints relative to the positions of known TSGs indicates that more than one gene may contribute to neuroblastoma pathogenesis. We evaluated the methylation status of semaphorin 3B (SEMA3B), one of the chromosome 3p TSGs, in neuroblastoma tumors with (n = 12) and without (n = 32) 3p deletions. A significantly higher percentage of methylated CpG sites in the SEMA3B promoter was detected in tumors exhibiting 3p loss (95%), relative to tumors without loss (52%), suggestive of a two-hit mechanism of allele inactivation. The involvement of methylation in the control of SEMA3B expression was confirmed by treatment of neuroblastoma cell lines with the demethylating agent 5-aza-2-deoxycytidine. Transcriptional regulation of this locus is complex, however; low levels of SEMA3B expression were also seen in tumors with unmethylated SEMA3B promoters (n = 4). SEMA3B is known to play an important role in the development of normal sympathetic neurons, and interestingly, we found higher levels of SEMA3B expression in differentiated tumors with favorable histopathology (n = 19) than in tumors with unfavorable histology (n = 22). Furthermore, SEMA3B was upregulated in the SK-N-BE neuroblastoma cell line following induction of differentiation with retinoic acid. The association of SEMA3B expression with neuroblastoma differentiation suggests that this TSG may play a role in neuroblastoma pathobiology." @default.
• W2074648081 created "2016-06-24" @default.
• W2074648081 creator A5005870476 @default.
• W2074648081 creator A5024810268 @default.
• W2074648081 creator A5035030496 @default.
• W2074648081 creator A5058569271 @default.
• W2074648081 creator A5085797243 @default.
• W2074648081 date "2007-04-01" @default.
• W2074648081 modified "2023-10-13" @default.
• W2074648081 title "High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene" @default.
• W2074648081 cites W1972621861 @default.
• W2074648081 cites W1979273476 @default.
• W2074648081 cites W1997937844 @default.
• W2074648081 cites W2022971351 @default.
• W2074648081 cites W2047200784 @default.
• W2074648081 cites W2053180817 @default.
• W2074648081 cites W2053827853 @default.
• W2074648081 cites W2061445402 @default.
• W2074648081 cites W2067606868 @default.
• W2074648081 cites W2068555261 @default.
• W2074648081 cites W2076663009 @default.
• W2074648081 cites W2100079176 @default.
• W2074648081 cites W2104093494 @default.
• W2074648081 cites W2108298260 @default.
• W2074648081 cites W2111746502 @default.
• W2074648081 cites W2127193805 @default.
• W2074648081 cites W2134409560 @default.
• W2074648081 cites W2136245178 @default.
• W2074648081 cites W2157389723 @default.
• W2074648081 cites W2157762137 @default.
• W2074648081 cites W2164318029 @default.
• W2074648081 cites W2167622058 @default.
• W2074648081 doi "https://doi.org/10.1016/j.cancergencyto.2006.11.017" @default.
• W2074648081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17452250" @default.
• W2074648081 hasPublicationYear "2007" @default.
• W2074648081 type Work @default.
• W2074648081 sameAs 2074648081 @default.
• W2074648081 citedByCount "38" @default.
• W2074648081 countsByYear W20746480812012 @default.
• W2074648081 countsByYear W20746480812013 @default.
• W2074648081 countsByYear W20746480812014 @default.
• W2074648081 countsByYear W20746480812015 @default.
• W2074648081 countsByYear W20746480812016 @default.
• W2074648081 countsByYear W20746480812017 @default.
• W2074648081 countsByYear W20746480812019 @default.
• W2074648081 countsByYear W20746480812020 @default.
• W2074648081 countsByYear W20746480812021 @default.
• W2074648081 countsByYear W20746480812023 @default.
• W2074648081 crossrefType "journal-article" @default.
• W2074648081 hasAuthorship W2074648081A5005870476 @default.
• W2074648081 hasAuthorship W2074648081A5024810268 @default.
• W2074648081 hasAuthorship W2074648081A5035030496 @default.
• W2074648081 hasAuthorship W2074648081A5058569271 @default.
• W2074648081 hasAuthorship W2074648081A5085797243 @default.
• W2074648081 hasConcept C104317684 @default.
• W2074648081 hasConcept C127716648 @default.
• W2074648081 hasConcept C143589142 @default.
• W2074648081 hasConcept C150194340 @default.
• W2074648081 hasConcept C153911025 @default.
• W2074648081 hasConcept C180754005 @default.
• W2074648081 hasConcept C190727270 @default.
• W2074648081 hasConcept C2776715637 @default.
• W2074648081 hasConcept C2778264664 @default.
• W2074648081 hasConcept C2779277951 @default.
• W2074648081 hasConcept C502942594 @default.
• W2074648081 hasConcept C54355233 @default.
• W2074648081 hasConcept C555283112 @default.
• W2074648081 hasConcept C68838962 @default.
• W2074648081 hasConcept C81885089 @default.
• W2074648081 hasConcept C86803240 @default.
• W2074648081 hasConceptScore W2074648081C104317684 @default.
• W2074648081 hasConceptScore W2074648081C127716648 @default.
• W2074648081 hasConceptScore W2074648081C143589142 @default.
• W2074648081 hasConceptScore W2074648081C150194340 @default.
• W2074648081 hasConceptScore W2074648081C153911025 @default.
• W2074648081 hasConceptScore W2074648081C180754005 @default.
• W2074648081 hasConceptScore W2074648081C190727270 @default.
• W2074648081 hasConceptScore W2074648081C2776715637 @default.
• W2074648081 hasConceptScore W2074648081C2778264664 @default.
• W2074648081 hasConceptScore W2074648081C2779277951 @default.
• W2074648081 hasConceptScore W2074648081C502942594 @default.
• W2074648081 hasConceptScore W2074648081C54355233 @default.
• W2074648081 hasConceptScore W2074648081C555283112 @default.
• W2074648081 hasConceptScore W2074648081C68838962 @default.
• W2074648081 hasConceptScore W2074648081C81885089 @default.
• W2074648081 hasConceptScore W2074648081C86803240 @default.
• W2074648081 hasIssue "2" @default.
• W2074648081 hasLocation W20746480811 @default.
• W2074648081 hasLocation W20746480812 @default.
• W2074648081 hasOpenAccess W2074648081 @default.
• W2074648081 hasPrimaryLocation W20746480811 @default.
• W2074648081 hasRelatedWork W1519595222 @default.
• W2074648081 hasRelatedWork W1925484557 @default.
• W2074648081 hasRelatedWork W1951189073 @default.
• W2074648081 hasRelatedWork W2028863756 @default.
• W2074648081 hasRelatedWork W2034700049 @default.
• W2074648081 hasRelatedWork W2122672020 @default.
• W2074648081 hasRelatedWork W2134251491 @default.

• next