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• W2074654321 abstract "Abstract We investigated whether commensal bacteria modulate activation and maturation of bone marrow‐derived DC and their ability to prime CD4 + T cells. We used Escherichia coli mpk, which induces colitis in gnotobiotic IL‐2‐deficient (IL‐2 –/– ) mice, and Bacteroides vulgatus mpk, which prevents E. coli ‐induced colitis. Stimulation of DC with E. coli induced TNF‐α, IL‐12 and IL‐6 secretion and expression of activation markers. Moreover, stimulation of DC with E. coli increased T cell activation and led to Th1 polarization. Stimulation with B. vulgatus led only to secretion of IL‐6, and DC were driven into a semi‐mature state with low expression of activation markers and did not promote Th1 responses. B. vulgatus ‐induced semi‐mature DC were non‐responsive to stimulation by E. coli in terms of maturation, T cell priming and TNF‐α but not IL‐6 production. The non‐responsiveness of B. vulgatus ‐stimulated DC was abrogated by addition of anti‐IL‐6 mAb or mimicked with rIL‐6. These data suggest that B. vulgatus ‐induced IL‐6 drives DC into a semi‐mature state in which they are non‐responsive to proinflammatory activation by E. coli . This in vitro mechanism might contribute to the prevention of E. coli ‐triggered colitis development by B. vulgatus in vivo ; high IL‐6 mRNA expression was consistently found in B. vulgatus ‐colonized or B. vulgatus/E. coli co‐colonized IL‐2 –/– mice and was associated with absence of colitis." @default.
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• W2074654321 date "2006-05-24" @default.
• W2074654321 modified "2023-10-15" @default.
• W2074654321 title "Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: An important role for IL-6" @default.
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• W2074654321 doi "https://doi.org/10.1002/eji.200635840" @default.
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