Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074654325> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2074654325 endingPage "392" @default.
- W2074654325 startingPage "388" @default.
- W2074654325 abstract "Topical methylglyoxal bis(guanylhydrazone) (MGBG) previously has been shown to produce partial clinical improvement in psoriasis. To enhance therapeutic activity, studies were undertaken to optimize MGBG percutaneous penetration in vitro and to study biochemical changes related to epidermal proliferation in vivo. MGBG penetration in saline, Vehicle N, decylmethylsulfoxide, and N-methylpyrrolidone was determined in normal human skin in vitro. Maximum penetration was obtained with 10% MGBG in Vehicle N (3 micrograms/h/cm2). Both topical and systemic MGBG resulted in increased levels of S-adenosyl-L-methionine decarboxylase, suggesting an extended half-life as a consequence of MGBG binding. Topical treatment with 10% MGBG in Vehicle N also resulted in decreased epidermal polyamine levels. The changes in polyamine metabolism were also associated with inhibition of epidermal DNA synthesis. These studies suggest that this topical MGBG formulation may be a candidate for use in the treatment of psoriasis and other hyperproliferative cutaneous diseases associated with increased polyamine synthesis." @default.
- W2074654325 created "2016-06-24" @default.
- W2074654325 creator A5013311518 @default.
- W2074654325 creator A5048281793 @default.
- W2074654325 creator A5088710519 @default.
- W2074654325 creator A5090106372 @default.
- W2074654325 date "1983-11-01" @default.
- W2074654325 modified "2023-09-26" @default.
- W2074654325 title "Percutaneous Penetration of Methylglyoxal Bis(guanylhydrazone): Effects on Hairless Mouse Epidermis In Vivo" @default.
- W2074654325 cites W1964056251 @default.
- W2074654325 cites W1971519806 @default.
- W2074654325 cites W1983589375 @default.
- W2074654325 cites W2005849570 @default.
- W2074654325 cites W2024889652 @default.
- W2074654325 cites W2057128278 @default.
- W2074654325 cites W2084675629 @default.
- W2074654325 cites W2086774965 @default.
- W2074654325 cites W2142744775 @default.
- W2074654325 cites W2281124822 @default.
- W2074654325 doi "https://doi.org/10.1111/1523-1747.ep12521980" @default.
- W2074654325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6415178" @default.
- W2074654325 hasPublicationYear "1983" @default.
- W2074654325 type Work @default.
- W2074654325 sameAs 2074654325 @default.
- W2074654325 citedByCount "5" @default.
- W2074654325 countsByYear W20746543252015 @default.
- W2074654325 crossrefType "journal-article" @default.
- W2074654325 hasAuthorship W2074654325A5013311518 @default.
- W2074654325 hasAuthorship W2074654325A5048281793 @default.
- W2074654325 hasAuthorship W2074654325A5088710519 @default.
- W2074654325 hasAuthorship W2074654325A5090106372 @default.
- W2074654325 hasBestOaLocation W20746543251 @default.
- W2074654325 hasConcept C127413603 @default.
- W2074654325 hasConcept C150903083 @default.
- W2074654325 hasConcept C181199279 @default.
- W2074654325 hasConcept C185592680 @default.
- W2074654325 hasConcept C202751555 @default.
- W2074654325 hasConcept C203014093 @default.
- W2074654325 hasConcept C207001950 @default.
- W2074654325 hasConcept C2777459323 @default.
- W2074654325 hasConcept C2778592357 @default.
- W2074654325 hasConcept C2779156968 @default.
- W2074654325 hasConcept C2780115381 @default.
- W2074654325 hasConcept C2780564577 @default.
- W2074654325 hasConcept C42475967 @default.
- W2074654325 hasConcept C54355233 @default.
- W2074654325 hasConcept C55493867 @default.
- W2074654325 hasConcept C71924100 @default.
- W2074654325 hasConcept C80107235 @default.
- W2074654325 hasConcept C86803240 @default.
- W2074654325 hasConcept C98274493 @default.
- W2074654325 hasConceptScore W2074654325C127413603 @default.
- W2074654325 hasConceptScore W2074654325C150903083 @default.
- W2074654325 hasConceptScore W2074654325C181199279 @default.
- W2074654325 hasConceptScore W2074654325C185592680 @default.
- W2074654325 hasConceptScore W2074654325C202751555 @default.
- W2074654325 hasConceptScore W2074654325C203014093 @default.
- W2074654325 hasConceptScore W2074654325C207001950 @default.
- W2074654325 hasConceptScore W2074654325C2777459323 @default.
- W2074654325 hasConceptScore W2074654325C2778592357 @default.
- W2074654325 hasConceptScore W2074654325C2779156968 @default.
- W2074654325 hasConceptScore W2074654325C2780115381 @default.
- W2074654325 hasConceptScore W2074654325C2780564577 @default.
- W2074654325 hasConceptScore W2074654325C42475967 @default.
- W2074654325 hasConceptScore W2074654325C54355233 @default.
- W2074654325 hasConceptScore W2074654325C55493867 @default.
- W2074654325 hasConceptScore W2074654325C71924100 @default.
- W2074654325 hasConceptScore W2074654325C80107235 @default.
- W2074654325 hasConceptScore W2074654325C86803240 @default.
- W2074654325 hasConceptScore W2074654325C98274493 @default.
- W2074654325 hasIssue "5" @default.
- W2074654325 hasLocation W20746543251 @default.
- W2074654325 hasLocation W20746543252 @default.
- W2074654325 hasOpenAccess W2074654325 @default.
- W2074654325 hasPrimaryLocation W20746543251 @default.
- W2074654325 hasRelatedWork W1968323570 @default.
- W2074654325 hasRelatedWork W2007023362 @default.
- W2074654325 hasRelatedWork W2008683710 @default.
- W2074654325 hasRelatedWork W2035646278 @default.
- W2074654325 hasRelatedWork W2074654325 @default.
- W2074654325 hasRelatedWork W2084989677 @default.
- W2074654325 hasRelatedWork W2137774676 @default.
- W2074654325 hasRelatedWork W2399408748 @default.
- W2074654325 hasRelatedWork W2414342311 @default.
- W2074654325 hasRelatedWork W2439982970 @default.
- W2074654325 hasVolume "81" @default.
- W2074654325 isParatext "false" @default.
- W2074654325 isRetracted "false" @default.
- W2074654325 magId "2074654325" @default.
- W2074654325 workType "article" @default.