FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074655100> ?p ?o ?g. }

• W2074655100 endingPage "435" @default.
• W2074655100 startingPage "425" @default.
• W2074655100 abstract "Interferon alpha-2b (IFN) alone or in combination with Ribavirin is approved in the United States for the treatment of chronic hepatitis C virus (HCV) infection. We have previously reported that the glucosidase inhibitor, n-butyl deoxynojirimycin (nB-DNJ) inhibits the production of infectious bovine diarrhea virus (BVDV) (Proc. Natl. Acad. Sci. 96 (1999) 11878). Since BVDV has been used as a model for HCV and grows productively in tissue culture, and IFN and glucosidase inhibitors are thought to act at different steps in the virus life cycle, it was of interest to determine the antiviral impact of combining nB-DNJ with IFN. Using plaque reduction and single-step growth analyses of the cytopathic BVDV strain NADL, data are presented that shows human IFN inhibited BVDV production in a dose dependent manner, with 3 IU/ml inhibiting 50% of the yield of virus (IC50) when added within 1 h post infection. Under the same conditions, the glucosidase inhibitors nB-DNJ and castanospermine (CST) also prevented BVDV production in a dose dependent manner with IC50s of 226 microM and 47 microM, respectively. In combination with 138 microM nB-DNJ the apparent IC50 for IFN was 0.056 IU/ml. This 54-fold increase in IFN potency suggests that nB-DNJ can synergize with IFN. Two additional independent analyses were performed to measure combination effects which demonstrated that the combined antiviral effect of nB-DNJ and IFN were greater than would be expected for a simple additivity. These data are consistent with an interpretation that glucosidase inhibitors and IFN have a synergistic antiviral effect in tissue culture. The relevance of these finding to treatment of HCV infection is discussed." @default.
• W2074655100 created "2016-06-24" @default.
• W2074655100 creator A5011600825 @default.
• W2074655100 creator A5019223116 @default.
• W2074655100 creator A5041693287 @default.
• W2074655100 creator A5062018516 @default.
• W2074655100 creator A5063944070 @default.
• W2074655100 date "2002-09-01" @default.
• W2074655100 modified "2023-10-17" @default.
• W2074655100 title "The combination of interferon α-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy" @default.
• W2074655100 cites W1491799435 @default.
• W2074655100 cites W1947717906 @default.
• W2074655100 cites W1968426124 @default.
• W2074655100 cites W1971311670 @default.
• W2074655100 cites W1976110218 @default.
• W2074655100 cites W1981745840 @default.
• W2074655100 cites W2018364492 @default.
• W2074655100 cites W2020746683 @default.
• W2074655100 cites W2025626805 @default.
• W2074655100 cites W2059457521 @default.
• W2074655100 cites W2067438899 @default.
• W2074655100 cites W2067953846 @default.
• W2074655100 cites W2089953168 @default.
• W2074655100 cites W2090562487 @default.
• W2074655100 cites W2100572271 @default.
• W2074655100 cites W2116648773 @default.
• W2074655100 cites W2116696460 @default.
• W2074655100 cites W2120055584 @default.
• W2074655100 cites W2129767605 @default.
• W2074655100 cites W2139729918 @default.
• W2074655100 cites W2143613583 @default.
• W2074655100 cites W2153632513 @default.
• W2074655100 cites W2158697492 @default.
• W2074655100 cites W2160063406 @default.
• W2074655100 cites W2165260654 @default.
• W2074655100 cites W2166086535 @default.
• W2074655100 cites W2253412804 @default.
• W2074655100 cites W2341829866 @default.
• W2074655100 doi "https://doi.org/10.1016/s0166-3542(02)00075-x" @default.
• W2074655100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12206880" @default.
• W2074655100 hasPublicationYear "2002" @default.
• W2074655100 type Work @default.
• W2074655100 sameAs 2074655100 @default.
• W2074655100 citedByCount "54" @default.
• W2074655100 countsByYear W20746551002012 @default.
• W2074655100 countsByYear W20746551002013 @default.
• W2074655100 countsByYear W20746551002014 @default.
• W2074655100 countsByYear W20746551002016 @default.
• W2074655100 countsByYear W20746551002017 @default.
• W2074655100 countsByYear W20746551002018 @default.
• W2074655100 countsByYear W20746551002019 @default.
• W2074655100 countsByYear W20746551002020 @default.
• W2074655100 countsByYear W20746551002021 @default.
• W2074655100 countsByYear W20746551002023 @default.
• W2074655100 crossrefType "journal-article" @default.
• W2074655100 hasAuthorship W2074655100A5011600825 @default.
• W2074655100 hasAuthorship W2074655100A5019223116 @default.
• W2074655100 hasAuthorship W2074655100A5041693287 @default.
• W2074655100 hasAuthorship W2074655100A5062018516 @default.
• W2074655100 hasAuthorship W2074655100A5063944070 @default.
• W2074655100 hasConcept C134040284 @default.
• W2074655100 hasConcept C159047783 @default.
• W2074655100 hasConcept C181199279 @default.
• W2074655100 hasConcept C202751555 @default.
• W2074655100 hasConcept C2522874641 @default.
• W2074655100 hasConcept C2775996393 @default.
• W2074655100 hasConcept C2776178377 @default.
• W2074655100 hasConcept C2776408679 @default.
• W2074655100 hasConcept C2780040827 @default.
• W2074655100 hasConcept C2781060939 @default.
• W2074655100 hasConcept C2781463415 @default.
• W2074655100 hasConcept C2909179924 @default.
• W2074655100 hasConcept C55493867 @default.
• W2074655100 hasConcept C86803240 @default.
• W2074655100 hasConceptScore W2074655100C134040284 @default.
• W2074655100 hasConceptScore W2074655100C159047783 @default.
• W2074655100 hasConceptScore W2074655100C181199279 @default.
• W2074655100 hasConceptScore W2074655100C202751555 @default.
• W2074655100 hasConceptScore W2074655100C2522874641 @default.
• W2074655100 hasConceptScore W2074655100C2775996393 @default.
• W2074655100 hasConceptScore W2074655100C2776178377 @default.
• W2074655100 hasConceptScore W2074655100C2776408679 @default.
• W2074655100 hasConceptScore W2074655100C2780040827 @default.
• W2074655100 hasConceptScore W2074655100C2781060939 @default.
• W2074655100 hasConceptScore W2074655100C2781463415 @default.
• W2074655100 hasConceptScore W2074655100C2909179924 @default.
• W2074655100 hasConceptScore W2074655100C55493867 @default.
• W2074655100 hasConceptScore W2074655100C86803240 @default.
• W2074655100 hasIssue "3" @default.
• W2074655100 hasLocation W20746551001 @default.
• W2074655100 hasLocation W20746551002 @default.
• W2074655100 hasOpenAccess W2074655100 @default.
• W2074655100 hasPrimaryLocation W20746551001 @default.
• W2074655100 hasRelatedWork W1971594025 @default.
• W2074655100 hasRelatedWork W2011835251 @default.
• W2074655100 hasRelatedWork W2061663807 @default.
• W2074655100 hasRelatedWork W2099076998 @default.
• W2074655100 hasRelatedWork W2108094816 @default.

• next