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- W2074657360 abstract "Rat striatal cells that were excited by cortical stimulation were found to respond to cortical stimulation with an average latency of 12 msec. Each response consisted of a variable number of spikes with, on the average, a less than 1:1 relationship between the stimulus and the number of spikes generated. Iontophoretic application of glutamic acid diethyl ester (GDEE), a substance reported to be a glutamate antagonist, at currents of +50 to +125 nA in the vicinity of neurons excited by cortical stimulation, almost totally suppressed the excitation in 90% of the cells, and this suppression was fully reversible. All cells were excited by glutamate. GDEE also suppressed neuronal excitation produced by iontophoretic aspartate, glutamate and dl-homocysteic acid. It is concluded from this study that an excitatory amino acid, either aspartic or glutamic, may function as the transmitter in the corticostriate projection." @default.
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- W2074657360 title "Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: Evidence for glutamic acid as an excitatory transmitter in the rat striatum" @default.
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- W2074657360 doi "https://doi.org/10.1016/0006-8993(76)90577-1" @default.
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