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- W2074657811 abstract "A full-length cDNA clone for aromatase P450 has been isolated from a pregnant mouse ovarian cDNA library. The insert of this clone (2394 bp) contains a 1509-bp open reading frame encoding 503 amino acid residues together with a 46-bp 5′-untranslated stretch and an 839-bp 3′-untranslated region to which a poly(A) tract is attached. Northern blot analysis of ovarian RNA from pregnant mice reveals a major mRNA band of 2.5 kb with a minor band of 2.1 kb. Comparison of mouse aromatase P450 with that of rat, human, and chicken shows 91, 81, and 69% identity in the nucleotide sequence and 92, 79, and 69% identity in the deduced amino acid sequence, respectively. The membrane-spanning domain of mouse aromatase P450 is estimated to be an extremely hydrophobic segment located within the N-terminal region of the molecule. Furthermore, a highly conserved heme-binding domain is noticed." @default.
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- W2074657811 date "1991-03-01" @default.
- W2074657811 modified "2023-10-18" @default.
- W2074657811 title "Isolation of a full-length cDNA encoding mouse aromatase P450" @default.
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- W2074657811 doi "https://doi.org/10.1016/0003-9861(91)90354-l" @default.
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