Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074658112> ?p ?o ?g. }
- W2074658112 endingPage "334" @default.
- W2074658112 startingPage "329" @default.
- W2074658112 abstract "Previously we observed that infection of HEp2 epithelial cells with Candida albicans results in HEp2 cell actin rearrangement as well as reduced membrane ruffling and motility and that supernatants of a C. albicans culture (Candida metabolite) caused the same changes. In this study, we used microarray analysis to determine changes in gene transcription of C. albicans following infection of HEp2 cells compared to control cultures grown in the absence of HEp2 cells. We observed 201 genes whose regulation was increased at least 2-fold following a 3 h incubation with HEp2 cells as well as 87 genes that are down-regulated. Among the up-regulated genes were ALS2 and ALS5 both of which encode proteins that provide an adherence function for C. albicans. To confirm the changes in ALS transcription, we measured by RT-PCR ALS1-9 at 1 h intervals for a total of 4 h. After 1 h of infection, several of the ALS genes were up-regulated compared to C. albicans grown alone. At 2–4 h, an increase in most of the ALS genes was observed in both infected and control cultures. ALS7 transcription was observed only at 3–4 h, but transcription was similar in both infected and control cultures. By RT-PCR, ALS2 and 5, similar to the microarray data, were significantly increased in infected cells at 3 h. Our results show that gene transcription following the adherence of C. albicans to HEp2 cells includes the up-regulation of genes encoding members of a family of known host recognition adhesins that may be critical to successful colonization and invasion of the organism." @default.
- W2074658112 created "2016-06-24" @default.
- W2074658112 creator A5006565021 @default.
- W2074658112 creator A5047131716 @default.
- W2074658112 creator A5079732497 @default.
- W2074658112 creator A5082531797 @default.
- W2074658112 date "2006-01-01" @default.
- W2074658112 modified "2023-10-16" @default.
- W2074658112 title "Gene transcription studies of<i>Candida albicans</i>following infection of HEp2 epithelial cells" @default.
- W2074658112 cites W1535701124 @default.
- W2074658112 cites W1756151797 @default.
- W2074658112 cites W1818280010 @default.
- W2074658112 cites W1837394676 @default.
- W2074658112 cites W1846492827 @default.
- W2074658112 cites W1966262091 @default.
- W2074658112 cites W1977190056 @default.
- W2074658112 cites W1978559750 @default.
- W2074658112 cites W1985245427 @default.
- W2074658112 cites W1993800351 @default.
- W2074658112 cites W1997119394 @default.
- W2074658112 cites W1997620426 @default.
- W2074658112 cites W2004093637 @default.
- W2074658112 cites W2037868823 @default.
- W2074658112 cites W2041394937 @default.
- W2074658112 cites W2044588968 @default.
- W2074658112 cites W2047682827 @default.
- W2074658112 cites W2068504042 @default.
- W2074658112 cites W2077434528 @default.
- W2074658112 cites W2078347406 @default.
- W2074658112 cites W2107215855 @default.
- W2074658112 cites W2112659088 @default.
- W2074658112 cites W2117464846 @default.
- W2074658112 cites W2118088795 @default.
- W2074658112 cites W2126450737 @default.
- W2074658112 cites W2126541230 @default.
- W2074658112 cites W2139620187 @default.
- W2074658112 cites W2144728717 @default.
- W2074658112 cites W2146168706 @default.
- W2074658112 cites W2147671956 @default.
- W2074658112 cites W2154156375 @default.
- W2074658112 cites W2158314241 @default.
- W2074658112 cites W4234311506 @default.
- W2074658112 cites W4245362352 @default.
- W2074658112 doi "https://doi.org/10.1080/13693780500434701" @default.
- W2074658112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16772226" @default.
- W2074658112 hasPublicationYear "2006" @default.
- W2074658112 type Work @default.
- W2074658112 sameAs 2074658112 @default.
- W2074658112 citedByCount "29" @default.
- W2074658112 countsByYear W20746581122012 @default.
- W2074658112 countsByYear W20746581122013 @default.
- W2074658112 countsByYear W20746581122014 @default.
- W2074658112 countsByYear W20746581122015 @default.
- W2074658112 countsByYear W20746581122017 @default.
- W2074658112 countsByYear W20746581122020 @default.
- W2074658112 countsByYear W20746581122021 @default.
- W2074658112 crossrefType "journal-article" @default.
- W2074658112 hasAuthorship W2074658112A5006565021 @default.
- W2074658112 hasAuthorship W2074658112A5047131716 @default.
- W2074658112 hasAuthorship W2074658112A5079732497 @default.
- W2074658112 hasAuthorship W2074658112A5082531797 @default.
- W2074658112 hasBestOaLocation W20746581121 @default.
- W2074658112 hasConcept C104317684 @default.
- W2074658112 hasConcept C138885662 @default.
- W2074658112 hasConcept C142669718 @default.
- W2074658112 hasConcept C145081991 @default.
- W2074658112 hasConcept C1491633281 @default.
- W2074658112 hasConcept C150194340 @default.
- W2074658112 hasConcept C153911025 @default.
- W2074658112 hasConcept C179926584 @default.
- W2074658112 hasConcept C186836561 @default.
- W2074658112 hasConcept C2780917455 @default.
- W2074658112 hasConcept C38676607 @default.
- W2074658112 hasConcept C41895202 @default.
- W2074658112 hasConcept C54355233 @default.
- W2074658112 hasConcept C8415881 @default.
- W2074658112 hasConcept C86339819 @default.
- W2074658112 hasConcept C86803240 @default.
- W2074658112 hasConcept C89423630 @default.
- W2074658112 hasConceptScore W2074658112C104317684 @default.
- W2074658112 hasConceptScore W2074658112C138885662 @default.
- W2074658112 hasConceptScore W2074658112C142669718 @default.
- W2074658112 hasConceptScore W2074658112C145081991 @default.
- W2074658112 hasConceptScore W2074658112C1491633281 @default.
- W2074658112 hasConceptScore W2074658112C150194340 @default.
- W2074658112 hasConceptScore W2074658112C153911025 @default.
- W2074658112 hasConceptScore W2074658112C179926584 @default.
- W2074658112 hasConceptScore W2074658112C186836561 @default.
- W2074658112 hasConceptScore W2074658112C2780917455 @default.
- W2074658112 hasConceptScore W2074658112C38676607 @default.
- W2074658112 hasConceptScore W2074658112C41895202 @default.
- W2074658112 hasConceptScore W2074658112C54355233 @default.
- W2074658112 hasConceptScore W2074658112C8415881 @default.
- W2074658112 hasConceptScore W2074658112C86339819 @default.
- W2074658112 hasConceptScore W2074658112C86803240 @default.
- W2074658112 hasConceptScore W2074658112C89423630 @default.
- W2074658112 hasIssue "4" @default.
- W2074658112 hasLocation W20746581121 @default.