FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074663977> ?p ?o ?g. }

• W2074663977 endingPage "77" @default.
• W2074663977 startingPage "67" @default.
• W2074663977 abstract "Close correlation between tissue transglutaminase (tTG) induction and growth regulation and/or cell death processes has been suggested in many cell lineages. In this study, the regulation of the tTG levels by various growth and differentiation factors and its relation to growth rate and cell death processes were investigated in two rat hepatoma cell lines, McA-RH7777 and McA-RH8994, using a monoclonal antibody against liver tTG. Transforming growth factor-β1 (TGF-β1) and retinoic acid (RA) each increased tTG to the level of 8- to 32-fold above that of control cultures in both cell lines after 72-h treatment. Dexamethasone (DEX) induced a 16- to 32-fold of tTG in McA-RH8994 cells while it did not change the enzyme level in McA-RH7777 cells. Simultaneous addition of DEX and RA increased the tTG level to more than 50-fold in McA-RH7777 cells as well as McA-RH8994 cells. Other factors, such as TGF-α, hepatocyte growth factor, dimethyl sulfoxide, and protein kinase C activator, did not show significant increases of the tTG levels. Although tTG induction by TGF-β1 or DEX appeared to be correlated with their growth suppressive effects, RA increased the tTG level without suppressing the growth rate of hepatoma cells. TGF-β1 was also shown to induce cell death in both cell lines. Our results demonstrate that RA and DEX are capable of modulating the TGF-β1-induced cell death processes independent of the tTG levels. We present evidence here that tTG induction by itself is not the direct cause of growth suppression and cell death in these hepatoma cells." @default.
• W2074663977 created "2016-06-24" @default.
• W2074663977 creator A5044584230 @default.
• W2074663977 creator A5051440907 @default.
• W2074663977 creator A5055441770 @default.
• W2074663977 date "1994-01-01" @default.
• W2074663977 modified "2023-09-27" @default.
• W2074663977 title "Differential regulation of tissue transglutaminase in rat hepatoma cell lines McA-RH7777 and McA-RH8994: Relation to growth rate and cell death" @default.
• W2074663977 cites W1486614317 @default.
• W2074663977 cites W1486999320 @default.
• W2074663977 cites W1504879193 @default.
• W2074663977 cites W1507890231 @default.
• W2074663977 cites W1516004503 @default.
• W2074663977 cites W1520668250 @default.
• W2074663977 cites W1550507433 @default.
• W2074663977 cites W1560399205 @default.
• W2074663977 cites W1577286351 @default.
• W2074663977 cites W1591434433 @default.
• W2074663977 cites W1595481029 @default.
• W2074663977 cites W1601147662 @default.
• W2074663977 cites W1892184508 @default.
• W2074663977 cites W1964041457 @default.
• W2074663977 cites W1984332162 @default.
• W2074663977 cites W1987297184 @default.
• W2074663977 cites W2008424960 @default.
• W2074663977 cites W2009577271 @default.
• W2074663977 cites W2010227424 @default.
• W2074663977 cites W2013475474 @default.
• W2074663977 cites W2017482945 @default.
• W2074663977 cites W2030408346 @default.
• W2074663977 cites W2040468468 @default.
• W2074663977 cites W2046980821 @default.
• W2074663977 cites W2050251876 @default.
• W2074663977 cites W2055191184 @default.
• W2074663977 cites W2059543986 @default.
• W2074663977 cites W2062890166 @default.
• W2074663977 cites W2063644279 @default.
• W2074663977 cites W2067189861 @default.
• W2074663977 cites W2072100568 @default.
• W2074663977 cites W2080308092 @default.
• W2074663977 cites W2084609653 @default.
• W2074663977 cites W2090962290 @default.
• W2074663977 cites W2140224540 @default.
• W2074663977 cites W2318157099 @default.
• W2074663977 cites W4211195301 @default.
• W2074663977 cites W4249224147 @default.
• W2074663977 doi "https://doi.org/10.1002/jcb.240540108" @default.
• W2074663977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7907335" @default.
• W2074663977 hasPublicationYear "1994" @default.
• W2074663977 type Work @default.
• W2074663977 sameAs 2074663977 @default.
• W2074663977 citedByCount "24" @default.
• W2074663977 countsByYear W20746639772013 @default.
• W2074663977 countsByYear W20746639772014 @default.
• W2074663977 crossrefType "journal-article" @default.
• W2074663977 hasAuthorship W2074663977A5044584230 @default.
• W2074663977 hasAuthorship W2074663977A5051440907 @default.
• W2074663977 hasAuthorship W2074663977A5055441770 @default.
• W2074663977 hasConcept C126322002 @default.
• W2074663977 hasConcept C134018914 @default.
• W2074663977 hasConcept C1491633281 @default.
• W2074663977 hasConcept C153911025 @default.
• W2074663977 hasConcept C170493617 @default.
• W2074663977 hasConcept C178498320 @default.
• W2074663977 hasConcept C181199279 @default.
• W2074663977 hasConcept C190283241 @default.
• W2074663977 hasConcept C2776996007 @default.
• W2074663977 hasConcept C2781121885 @default.
• W2074663977 hasConcept C31573885 @default.
• W2074663977 hasConcept C54355233 @default.
• W2074663977 hasConcept C55493867 @default.
• W2074663977 hasConcept C62112901 @default.
• W2074663977 hasConcept C71924100 @default.
• W2074663977 hasConcept C81885089 @default.
• W2074663977 hasConcept C86803240 @default.
• W2074663977 hasConceptScore W2074663977C126322002 @default.
• W2074663977 hasConceptScore W2074663977C134018914 @default.
• W2074663977 hasConceptScore W2074663977C1491633281 @default.
• W2074663977 hasConceptScore W2074663977C153911025 @default.
• W2074663977 hasConceptScore W2074663977C170493617 @default.
• W2074663977 hasConceptScore W2074663977C178498320 @default.
• W2074663977 hasConceptScore W2074663977C181199279 @default.
• W2074663977 hasConceptScore W2074663977C190283241 @default.
• W2074663977 hasConceptScore W2074663977C2776996007 @default.
• W2074663977 hasConceptScore W2074663977C2781121885 @default.
• W2074663977 hasConceptScore W2074663977C31573885 @default.
• W2074663977 hasConceptScore W2074663977C54355233 @default.
• W2074663977 hasConceptScore W2074663977C55493867 @default.
• W2074663977 hasConceptScore W2074663977C62112901 @default.
• W2074663977 hasConceptScore W2074663977C71924100 @default.
• W2074663977 hasConceptScore W2074663977C81885089 @default.
• W2074663977 hasConceptScore W2074663977C86803240 @default.
• W2074663977 hasIssue "1" @default.
• W2074663977 hasLocation W20746639771 @default.
• W2074663977 hasLocation W20746639772 @default.
• W2074663977 hasOpenAccess W2074663977 @default.
• W2074663977 hasPrimaryLocation W20746639771 @default.
• W2074663977 hasRelatedWork W1972963040 @default.

• next