Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074665635> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2074665635 endingPage "1353" @default.
- W2074665635 startingPage "1342" @default.
- W2074665635 abstract "The effects of therapeutic levels of quinidine were studied in an ischemic gap preparation of reflected reentry. The preparation consisted of a Purkinje fiber mounted in a three-compartment chamber. A narrow central compartment was perfused with a solution prepared to mimic the extracellular milieu at a site of ischemia. Quinidine in concentrations that exert little effect on normal Purkinje tissue, 1 to 2 micrograms/ml, greatly impaired conduction and markedly prolonged refractoriness across the ischemic gap. The drug effected these changes by (1) extending the inexcitable zone within the depressed region, (2) decreasing the amplitude of the input signal entering this zone, and (3) decreasing the excitability of the tissue beyond the depressed zone (evaluated by current clamp techniques). These actions of the drug produced both antiarrhythmic and proarrhythmic effects. When the initial level of conduction impairment was high, quinidine totally suppressed reflected reentry at all frequencies by precipitating complete anterograde conduction block. At intermediate levels of block, the drug generally caused a prominent shift of the frequency dependence of reentrant activity to lower stimulation rates. Finally, when conduction was relatively less impaired, quinidine created the conditions for reflected reentry to occur. Our results suggest that the heart rate dependence of reentrant arrhythmias might be of prognostic value in the administration of antiarrhythmic drugs." @default.
- W2074665635 created "2016-06-24" @default.
- W2074665635 creator A5005749391 @default.
- W2074665635 creator A5028491456 @default.
- W2074665635 date "1986-06-01" @default.
- W2074665635 modified "2023-09-27" @default.
- W2074665635 title "Mechanisms underlying the antiarrhythmic and arrhythmogenic actions of quinidine in a Purkinje fiber-ischemic gap preparation of reflected reentry." @default.
- W2074665635 cites W1967503377 @default.
- W2074665635 cites W1990332198 @default.
- W2074665635 cites W1998782346 @default.
- W2074665635 cites W2011261337 @default.
- W2074665635 cites W2015169899 @default.
- W2074665635 cites W2020765756 @default.
- W2074665635 cites W2031736892 @default.
- W2074665635 cites W2032877182 @default.
- W2074665635 cites W2038203329 @default.
- W2074665635 cites W2040441083 @default.
- W2074665635 cites W2053053166 @default.
- W2074665635 cites W2055166534 @default.
- W2074665635 cites W2056547258 @default.
- W2074665635 cites W2059306254 @default.
- W2074665635 cites W2064394177 @default.
- W2074665635 cites W2069884282 @default.
- W2074665635 cites W2081278908 @default.
- W2074665635 cites W2103284011 @default.
- W2074665635 cites W2188808438 @default.
- W2074665635 cites W2412052501 @default.
- W2074665635 cites W59763187 @default.
- W2074665635 doi "https://doi.org/10.1161/01.cir.73.6.1342" @default.
- W2074665635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3698260" @default.
- W2074665635 hasPublicationYear "1986" @default.
- W2074665635 type Work @default.
- W2074665635 sameAs 2074665635 @default.
- W2074665635 citedByCount "11" @default.
- W2074665635 countsByYear W20746656352016 @default.
- W2074665635 crossrefType "journal-article" @default.
- W2074665635 hasAuthorship W2074665635A5005749391 @default.
- W2074665635 hasAuthorship W2074665635A5028491456 @default.
- W2074665635 hasBestOaLocation W20746656351 @default.
- W2074665635 hasConcept C104397207 @default.
- W2074665635 hasConcept C126322002 @default.
- W2074665635 hasConcept C164705383 @default.
- W2074665635 hasConcept C185263204 @default.
- W2074665635 hasConcept C2777463368 @default.
- W2074665635 hasConcept C2777720157 @default.
- W2074665635 hasConcept C2780040984 @default.
- W2074665635 hasConcept C2780339425 @default.
- W2074665635 hasConcept C42219234 @default.
- W2074665635 hasConcept C70616116 @default.
- W2074665635 hasConcept C71924100 @default.
- W2074665635 hasConceptScore W2074665635C104397207 @default.
- W2074665635 hasConceptScore W2074665635C126322002 @default.
- W2074665635 hasConceptScore W2074665635C164705383 @default.
- W2074665635 hasConceptScore W2074665635C185263204 @default.
- W2074665635 hasConceptScore W2074665635C2777463368 @default.
- W2074665635 hasConceptScore W2074665635C2777720157 @default.
- W2074665635 hasConceptScore W2074665635C2780040984 @default.
- W2074665635 hasConceptScore W2074665635C2780339425 @default.
- W2074665635 hasConceptScore W2074665635C42219234 @default.
- W2074665635 hasConceptScore W2074665635C70616116 @default.
- W2074665635 hasConceptScore W2074665635C71924100 @default.
- W2074665635 hasIssue "6" @default.
- W2074665635 hasLocation W20746656351 @default.
- W2074665635 hasLocation W20746656352 @default.
- W2074665635 hasOpenAccess W2074665635 @default.
- W2074665635 hasPrimaryLocation W20746656351 @default.
- W2074665635 hasRelatedWork W1973833356 @default.
- W2074665635 hasRelatedWork W1984374161 @default.
- W2074665635 hasRelatedWork W2001078967 @default.
- W2074665635 hasRelatedWork W2008773357 @default.
- W2074665635 hasRelatedWork W2045228164 @default.
- W2074665635 hasRelatedWork W2055725273 @default.
- W2074665635 hasRelatedWork W2074665635 @default.
- W2074665635 hasRelatedWork W2086276398 @default.
- W2074665635 hasRelatedWork W2151785536 @default.
- W2074665635 hasRelatedWork W2161845442 @default.
- W2074665635 hasVolume "73" @default.
- W2074665635 isParatext "false" @default.
- W2074665635 isRetracted "false" @default.
- W2074665635 magId "2074665635" @default.
- W2074665635 workType "article" @default.