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• W2074670391 abstract "We read the review article titled “Familial Hypercholesterolemia: An Under-recognized but Significant Concern in Cardiology Practice” by Professor Foody with great interest. Prof. Foody described the cardiologists' knowledge of familial hypercholesterolemia (FH), highlighting serious knowledge gaps in the prevalence, inheritance, and risk of premature cardiovascular disease, and that fewer than 30% of cardiologists were able to recognize a typical case of FH.1 In our experience, cardiologists' knowledge of FH was highly comparable to primary care physicians (general practitioners). We conducted a study of 191 primary care physicians who also demonstrated knowledge deficiencies in prevalence, inheritance, and recognition of the clinical features of FH, with correct responses provided by 27%, 45%, and 38%, respectively (Table 1).2 We have also demonstrated that pharmacists have similar knowledge deficiencies, with only 11%, 27%, and 46% identifying the correct prevalence, inheritance, and typical lipid profile of FH, respectively.3 The low awareness and knowledge of FH among all of these healthcare professionals is concerning, as FH is the most prevalent monogenic lipid disorder predisposing to premature cardiovascular disease, with strong evidence that early treatment improves outcome.4-6 Currently, the majority of people with FH worldwide are undiagnosed or untreated.6, 7 Specialists and primary care providers require education and awareness campaigns to optimize FH management and reduce the burden of premature vascular disease. Opportunistic detection of FH can occur in multiple settings if the severity and inheritance of FH are recognized. It was concerning that <50% of cardiologists1 and primary care physicians2 did not recognize that 1 in 2 first-degree relatives of a person with FH would also be expected to have FH. This suggests there is a lost opportunity for screening family members for FH (cascade screening). Cascade screening for FH is cost-effective,8 and is recommended for children and adults worldwide.5-7, 9, 10 A multidisciplinary approach to FH management is required given the magnitude of underdiagnosis and undertreatment of this condition. This may involve novel strategies. For example, the community laboratory is well placed to perform opportunistic FH screening, as they perform large volumes of low-density lipoprotein cholesterol tests, and primary care physicians report that interpretative comments on laboratory results are useful to highlight that their patient is at risk of FH.2, 11 However, the most effective method of ensuring these people are then referred to a specialist remains to be determined.12 Damon A. Bell, MBChB, FRACP, FRCPA School of Medicine and Pharmacology University of Western Australia Department of Clinical Biochemistry Lipid Disorders Clinic, Cardiometabolic Service Department of Internal Medicine Royal Perth Hospital Perth, Australia Gerald F. Watts, DSc MB BS, PhD, DM, FRCP, FRACP School of Medicine and Pharmacology University of Western Australia Lipid Disorders Clinic, Cardiometabolic Service Department of Internal Medicine Royal Perth Hospital Perth, Australia" @default.
• W2074670391 created "2016-06-24" @default.
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• W2074670391 date "2014-02-12" @default.
• W2074670391 modified "2023-10-14" @default.
• W2074670391 title "Response to Familial Hypercholesterolemia: An Under-recognized but Significant Concern in Cardiology Practice Foody JM et al. Clin Cardiol. doi: 10.1002/clc.22223." @default.
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• W2074670391 doi "https://doi.org/10.1002/clc.22257" @default.
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