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• W2074678468 abstract "Total lymphocyte counts, B-, T-, C93 receptor-bearing lymphocytes, and K-cell activity were studied in peripheral blood in patients with Crohn9s disease and inflammatory liver disease. Patients with active untreated Crohn9s disease and acute virus B hepatitis exhibited a markedly increased K-cell activity measured in a plaque assay when compared with normal controls (P less than 0.01). Patients with immunosuppressive treated Crohn9s disease, HBsAg-positive chronic active hepatitis, and cirrhosis of the liver showed only a slight increase of K-cell activity (P less than 0.01). In the postacute phase of hepatitis (four to 12 weeks from onset) K-cell activity fell to normal levels. The number of B-lymphocytes showed a relative and absolute decrease in all groups of patients. With the exception of patients with acute HBsAg-positive hepatitis and the post-acute phase of hepatitis all the other groups showed statistically decreased absolute numbers for C93 receptor-bearing lymphocytes. The significant decrease in K-cell activity and the number of T-lymphocytes in Crohn9s disease treated with immunosuppressive drugs was interpreted as an effect of azathioprine and prednisone on these lymphocyte subpopulations." @default.
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• W2074678468 date "1977-12-01" @default.
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• W2074678468 title "K-lymphocytes (killer-cells) in Crohn's disease and acute virus B-hepatitis." @default.
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• W2074678468 doi "https://doi.org/10.1136/gut.18.12.1010" @default.
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