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- W207468664 endingPage "535" @default.
- W207468664 startingPage "499" @default.
- W207468664 abstract "Within the past decade, molecular cloning techniques have confirmed that 5-hydroxytryptamine (5-HT) receptor subtypes, originally predicted from radioligand binding and functional studies (e.g., 5-HT1, 5-HT2, 5-HT3, 5-HT4), represent separate and distinct gene products. This knowledge has had a crucial impact on electrophysiological approaches to the 5-HT system in two important ways: (1) studies on previously recognized 5-HT receptors are now being directed, through the use of in situ mRNA hybridization and immunocytochemical maps, more precisely toward neurons that express these specific 5-HT receptor subtypes and (2) the functional role of previously unrecognized receptors (e.g., 5-HT5, 5-HT6, 5-HT7) can now be explored. Depending on the expression pattern for each type of neuron, the various 5-HT receptor subtypes can interact with their own set of G proteins, second messengers, and ion channels, to give rise to the wide range of electrophysiological actions produced by 5-HT throughout the brain and spinal cord. In addition, it is becoming evident that more than one 5-HT receptor sub-type may be expressed by the same neuron or by different neurons within the same region. Thus, while the following review is organized primarily according to individual 5-HT receptor subtypes, interactions between different receptor subtypes within a single neuron or region are also discussed where appropriate." @default.
- W207468664 created "2016-06-24" @default.
- W207468664 creator A5032595661 @default.
- W207468664 creator A5083475801 @default.
- W207468664 date "2000-01-01" @default.
- W207468664 modified "2023-09-27" @default.
- W207468664 title "Electrophysiology of 5-HT Receptors" @default.
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