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- W2074691878 abstract "Scatchard analysis of 3H-dihydromorphine (3H-DHM) binding to rat brain subcellular fractions gave a curvilinear plot in the microsomal (P3) and a linear plot in the mitochondrial (P2) fraction, respectively. In contrast, plots of 3H-ethylketocyclazocine (3H-EK) binding were linear in the P3 and curvilinear in the P2 fraction. No differences were seen in the potency of morphine and ketazocine in displacing either 3H-DHM or 3H-EK in the P2 fraction. In the P3 fraction, however, morphine was more potent than ketazocine in displacing 3H-DHM, but the reverse was true when 3H-EK was used as the ligand. Isolation of the P3 fraction may facilitate the demonstration of a kappa receptor in the rat brain." @default.
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- W2074691878 date "1982-09-01" @default.
- W2074691878 modified "2023-09-26" @default.
- W2074691878 title "Binding characteristics of μ and κ agonists in rat brain subcellular fractions" @default.
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- W2074691878 doi "https://doi.org/10.1016/0024-3205(82)90365-4" @default.
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