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• W2074699913 abstract "Circulating antibodies to myeloperoxidase (MPO) are associated primarily with pauci-immune glomerulonephritis and systemic vasculitis. Anti-MPO antibodies belong to a group of autoantibodies, anti-neutrophil cytoplasmic antibodies, that may play a pathogenic role in vasculitis. We have generated a human monoclonal anti-MPO antibody (E3-MPO) using peripheral blood lymphocytes from a patient with microscopic polyarteritis. Variable region gene analysis of E3-MPO showed that the VH region had 90% homology with the germ line gene VH4-21. E3-MPO was also shown to carry the 9G4 idiotope, which so far has been associated only with human antibodies that utilize the VH4-21 gene. The 9G4 idiotope was also expressed on anti-MPO antibodies in sera from the donor patient and from 4/7 additional patients with active, untreated vasculitis. The nucleotide sequences of both the variable heavy and light chains of E3-MPO showed evidence of an antigen-driven response." @default.
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• W2074699913 date "1996-02-01" @default.
• W2074699913 modified "2023-09-26" @default.
• W2074699913 title "Analysis of immunoglobulin variable region genes of a human IgM anti‐myeloperoxidase antibody derived from a patient with vasculitis" @default.
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• W2074699913 doi "https://doi.org/10.1046/j.1365-2567.1996.463529.x" @default.
• W2074699913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1384293" @default.
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