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• W2074702959 abstract "The physiological and pharmacological properties of two classes of putative nociceptive modulatory neurons have been extensively characterized in the rostral ventromedial medulla (RVM) of the barbiturate-anesthetized rat. ‘On-cells’ show a burst of activity, and ‘off-cells’ a sudden pause immediately preceding the occurence of nocifensor reflexes. In the present study, we have characterized the reflex-related activity of RVM neurons in halothane-anesthetized rats to determine whether the properties of these neurons are dependent on barbiturate anesthesia. Both on- and off-cells were identified in this preparation. Repeated noxious stimulation was associated with a high level of ongoing activity in on-cells, and a low level in off-cells. These data thus demonstrate that the previously described reflex-related changes in RVM neuron activity are not specific to barbiturate-anesthetized preparations, and that a failure to demonstrate off-cells in some studies may result from these neurons being inactive following repeated testing with noxious stimuli." @default.
• W2074702959 created "2016-06-24" @default.
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• W2074702959 date "1992-06-01" @default.
• W2074702959 modified "2023-10-16" @default.
• W2074702959 title "Activity of neurons in the rostral medulla of the halothane-anesthetized rat during withdrawal from noxious heat" @default.
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• W2074702959 doi "https://doi.org/10.1016/0006-8993(92)90331-3" @default.
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