FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074718135> ?p ?o ?g. }

• W2074718135 endingPage "395" @default.
• W2074718135 startingPage "390" @default.
• W2074718135 abstract "(2E)-2-{6-[(E)-2-carboxylvinyl]-2,3-dihydroxyphenyl}-3-(3,4-dihydroxyphenyl) propenoic acid, a novel compound designated SMND-309, is a new metabolite of salvianolic acid B. The present study was carried out to investigate the effects of SMND-309 on experimental liver fibrosis in rats induced by subcutaneous injection of carbon tetrachloride and explore its possible mechanisms on the basis of biochemical, histopathologic and immunohistochemical studies. The results showed that intragastrical treatment with SMND-309 ameliorated liver function and decreased the elevation of serum hyaluronic acid, laminin, procollagen type III levels and hydroxyproline content in liver tissue. It also decreased the elevation in the malondialdehyde level and restored the decrease in superoxide dismutase and glutathione peroxidase activities. Upon histopathologic examination, the SMND-309-treated rats reduced the liver damage and the liver fibrosis grade. Moreover, the results of immunohistochemical examination showed that SMND-309 powerfully down-regulated the expression of connective tissue growth factor (CTGF) rather than transforming growth factor-beta1 (TGF-β1) in serum and liver. Meanwhile, SMND-309 exhibits significantly higher potency compared with salvianolic acid B (Sal B) at the same dose. The antifibrotic mechanisms of SMND-309 might be associated with its ability to suppress the expression of CTGF as well as scavenge lipid peroxidation products and increase endogenous antioxidant enzyme activity." @default.
• W2074718135 created "2016-06-24" @default.
• W2074718135 creator A5005715557 @default.
• W2074718135 creator A5040324875 @default.
• W2074718135 creator A5040915613 @default.
• W2074718135 creator A5045858633 @default.
• W2074718135 creator A5071725354 @default.
• W2074718135 date "2011-01-01" @default.
• W2074718135 modified "2023-10-18" @default.
• W2074718135 title "Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis" @default.
• W2074718135 cites W1529117373 @default.
• W2074718135 cites W1969992614 @default.
• W2074718135 cites W1976599453 @default.
• W2074718135 cites W1992687015 @default.
• W2074718135 cites W1992897849 @default.
• W2074718135 cites W1997474235 @default.
• W2074718135 cites W2002991607 @default.
• W2074718135 cites W2008885108 @default.
• W2074718135 cites W2017961355 @default.
• W2074718135 cites W2035008602 @default.
• W2074718135 cites W2044069347 @default.
• W2074718135 cites W2055215119 @default.
• W2074718135 cites W2063242845 @default.
• W2074718135 cites W2068689621 @default.
• W2074718135 cites W20724912 @default.
• W2074718135 cites W2084407248 @default.
• W2074718135 cites W2085153336 @default.
• W2074718135 cites W2093210803 @default.
• W2074718135 cites W2103031848 @default.
• W2074718135 cites W2122808924 @default.
• W2074718135 cites W2154557709 @default.
• W2074718135 cites W2158129157 @default.
• W2074718135 cites W2171337302 @default.
• W2074718135 cites W4212985336 @default.
• W2074718135 doi "https://doi.org/10.1016/j.ejphar.2010.10.019" @default.
• W2074718135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20969856" @default.
• W2074718135 hasPublicationYear "2011" @default.
• W2074718135 type Work @default.
• W2074718135 sameAs 2074718135 @default.
• W2074718135 citedByCount "21" @default.
• W2074718135 countsByYear W20747181352012 @default.
• W2074718135 countsByYear W20747181352013 @default.
• W2074718135 countsByYear W20747181352014 @default.
• W2074718135 countsByYear W20747181352015 @default.
• W2074718135 countsByYear W20747181352016 @default.
• W2074718135 countsByYear W20747181352017 @default.
• W2074718135 countsByYear W20747181352018 @default.
• W2074718135 countsByYear W20747181352019 @default.
• W2074718135 countsByYear W20747181352020 @default.
• W2074718135 countsByYear W20747181352021 @default.
• W2074718135 countsByYear W20747181352022 @default.
• W2074718135 countsByYear W20747181352023 @default.
• W2074718135 crossrefType "journal-article" @default.
• W2074718135 hasAuthorship W2074718135A5005715557 @default.
• W2074718135 hasAuthorship W2074718135A5040324875 @default.
• W2074718135 hasAuthorship W2074718135A5040915613 @default.
• W2074718135 hasAuthorship W2074718135A5045858633 @default.
• W2074718135 hasAuthorship W2074718135A5071725354 @default.
• W2074718135 hasConcept C105702510 @default.
• W2074718135 hasConcept C126322002 @default.
• W2074718135 hasConcept C134018914 @default.
• W2074718135 hasConcept C142724271 @default.
• W2074718135 hasConcept C170493617 @default.
• W2074718135 hasConcept C178790620 @default.
• W2074718135 hasConcept C185592680 @default.
• W2074718135 hasConcept C2775838275 @default.
• W2074718135 hasConcept C2775960820 @default.
• W2074718135 hasConcept C2777359374 @default.
• W2074718135 hasConcept C2777477808 @default.
• W2074718135 hasConcept C2777529286 @default.
• W2074718135 hasConcept C2778004101 @default.
• W2074718135 hasConcept C2778401633 @default.
• W2074718135 hasConcept C2778760513 @default.
• W2074718135 hasConcept C2779797417 @default.
• W2074718135 hasConcept C2780559512 @default.
• W2074718135 hasConcept C2780631158 @default.
• W2074718135 hasConcept C2780829032 @default.
• W2074718135 hasConcept C2993667909 @default.
• W2074718135 hasConcept C518705261 @default.
• W2074718135 hasConcept C55493867 @default.
• W2074718135 hasConcept C71924100 @default.
• W2074718135 hasConcept C98274493 @default.
• W2074718135 hasConceptScore W2074718135C105702510 @default.
• W2074718135 hasConceptScore W2074718135C126322002 @default.
• W2074718135 hasConceptScore W2074718135C134018914 @default.
• W2074718135 hasConceptScore W2074718135C142724271 @default.
• W2074718135 hasConceptScore W2074718135C170493617 @default.
• W2074718135 hasConceptScore W2074718135C178790620 @default.
• W2074718135 hasConceptScore W2074718135C185592680 @default.
• W2074718135 hasConceptScore W2074718135C2775838275 @default.
• W2074718135 hasConceptScore W2074718135C2775960820 @default.
• W2074718135 hasConceptScore W2074718135C2777359374 @default.
• W2074718135 hasConceptScore W2074718135C2777477808 @default.
• W2074718135 hasConceptScore W2074718135C2777529286 @default.
• W2074718135 hasConceptScore W2074718135C2778004101 @default.
• W2074718135 hasConceptScore W2074718135C2778401633 @default.
• W2074718135 hasConceptScore W2074718135C2778760513 @default.
• W2074718135 hasConceptScore W2074718135C2779797417 @default.

• next