FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074724011> ?p ?o ?g. }

• W2074724011 endingPage "534" @default.
• W2074724011 startingPage "529" @default.
• W2074724011 abstract "Liposomes have proven their use as a tool in various immunological studies. In our own studies, both their application as antigen carriers and as drug carriers appeared to be useful. Immune responses were elicited against free soluble protein antigens and against the same antigens in a liposome-associated (particulate) form, in order to compare both types of response. Since we were especially interested in the role of splenic macrophages in both types of response, we developed a liposome-mediated macrophage suicide approach, based on the liposome-mediated internalization of the small hydrophilic molecule clodronate in macrophages. This molecule has a very short half life when released in the circulation, but does not easily cross phospholipid bilayers of liposomes or cell membranes. As a consequence, once ingested by a macrophage in a liposome-encapsulated form, it will be accumulated within the cell as soon as the liposomes are digested with the help of its lysosomal phospholipases. At a certain intracellular clodronate concentration, the macrophage is eliminated by apoptosis. Given the fact that neither the liposomal phospholipids chosen nor clodronate are toxic to other (non-phagocytic) cells, this method has proven its efficacy for depletion of macrophage subsets in various organs. In several cases, organ-specific depletion can be obtained by choosing the right administration route for the clodronate liposomes." @default.
• W2074724011 created "2016-06-24" @default.
• W2074724011 creator A5079003683 @default.
• W2074724011 date "2008-01-01" @default.
• W2074724011 modified "2023-09-25" @default.
• W2074724011 title "Liposomes for targeting of antigens and drugs: Immunoadjuvant activity and liposome-mediated depletion of macrophages" @default.
• W2074724011 cites W1210607603 @default.
• W2074724011 cites W1592595415 @default.
• W2074724011 cites W1956258286 @default.
• W2074724011 cites W1963895695 @default.
• W2074724011 cites W1978002868 @default.
• W2074724011 cites W1988925907 @default.
• W2074724011 cites W1993262247 @default.
• W2074724011 cites W1993677761 @default.
• W2074724011 cites W1994723172 @default.
• W2074724011 cites W1997653917 @default.
• W2074724011 cites W1998907409 @default.
• W2074724011 cites W2026491444 @default.
• W2074724011 cites W2032131088 @default.
• W2074724011 cites W2039373267 @default.
• W2074724011 cites W2042644461 @default.
• W2074724011 cites W2049746813 @default.
• W2074724011 cites W2064756683 @default.
• W2074724011 cites W2065840171 @default.
• W2074724011 cites W2077675327 @default.
• W2074724011 cites W2090371453 @default.
• W2074724011 cites W2103711259 @default.
• W2074724011 cites W2107370389 @default.
• W2074724011 cites W2112730454 @default.
• W2074724011 cites W2126696395 @default.
• W2074724011 cites W2183796854 @default.
• W2074724011 cites W2184434686 @default.
• W2074724011 cites W2377936835 @default.
• W2074724011 cites W2409658494 @default.
• W2074724011 cites W3025036998 @default.
• W2074724011 cites W4240210710 @default.
• W2074724011 doi "https://doi.org/10.1080/10611860802228426" @default.
• W2074724011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18686122" @default.
• W2074724011 hasPublicationYear "2008" @default.
• W2074724011 type Work @default.
• W2074724011 sameAs 2074724011 @default.
• W2074724011 citedByCount "24" @default.
• W2074724011 countsByYear W20747240112013 @default.
• W2074724011 countsByYear W20747240112014 @default.
• W2074724011 countsByYear W20747240112015 @default.
• W2074724011 countsByYear W20747240112016 @default.
• W2074724011 countsByYear W20747240112018 @default.
• W2074724011 countsByYear W20747240112019 @default.
• W2074724011 countsByYear W20747240112021 @default.
• W2074724011 countsByYear W20747240112022 @default.
• W2074724011 crossrefType "journal-article" @default.
• W2074724011 hasAuthorship W2074724011A5079003683 @default.
• W2074724011 hasConcept C13245373 @default.
• W2074724011 hasConcept C139770010 @default.
• W2074724011 hasConcept C147483822 @default.
• W2074724011 hasConcept C1491633281 @default.
• W2074724011 hasConcept C160448771 @default.
• W2074724011 hasConcept C185154212 @default.
• W2074724011 hasConcept C185592680 @default.
• W2074724011 hasConcept C202751555 @default.
• W2074724011 hasConcept C203014093 @default.
• W2074724011 hasConcept C2778918659 @default.
• W2074724011 hasConcept C2779244956 @default.
• W2074724011 hasConcept C2780035454 @default.
• W2074724011 hasConcept C28005876 @default.
• W2074724011 hasConcept C2909935589 @default.
• W2074724011 hasConcept C40017333 @default.
• W2074724011 hasConcept C41625074 @default.
• W2074724011 hasConcept C55493867 @default.
• W2074724011 hasConcept C86803240 @default.
• W2074724011 hasConcept C8891405 @default.
• W2074724011 hasConcept C95444343 @default.
• W2074724011 hasConcept C98274493 @default.
• W2074724011 hasConceptScore W2074724011C13245373 @default.
• W2074724011 hasConceptScore W2074724011C139770010 @default.
• W2074724011 hasConceptScore W2074724011C147483822 @default.
• W2074724011 hasConceptScore W2074724011C1491633281 @default.
• W2074724011 hasConceptScore W2074724011C160448771 @default.
• W2074724011 hasConceptScore W2074724011C185154212 @default.
• W2074724011 hasConceptScore W2074724011C185592680 @default.
• W2074724011 hasConceptScore W2074724011C202751555 @default.
• W2074724011 hasConceptScore W2074724011C203014093 @default.
• W2074724011 hasConceptScore W2074724011C2778918659 @default.
• W2074724011 hasConceptScore W2074724011C2779244956 @default.
• W2074724011 hasConceptScore W2074724011C2780035454 @default.
• W2074724011 hasConceptScore W2074724011C28005876 @default.
• W2074724011 hasConceptScore W2074724011C2909935589 @default.
• W2074724011 hasConceptScore W2074724011C40017333 @default.
• W2074724011 hasConceptScore W2074724011C41625074 @default.
• W2074724011 hasConceptScore W2074724011C55493867 @default.
• W2074724011 hasConceptScore W2074724011C86803240 @default.
• W2074724011 hasConceptScore W2074724011C8891405 @default.
• W2074724011 hasConceptScore W2074724011C95444343 @default.
• W2074724011 hasConceptScore W2074724011C98274493 @default.
• W2074724011 hasIssue "7-8" @default.
• W2074724011 hasLocation W20747240111 @default.
• W2074724011 hasLocation W20747240112 @default.
• W2074724011 hasOpenAccess W2074724011 @default.

• next