FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074728660> ?p ?o ?g. }

• W2074728660 endingPage "1261" @default.
• W2074728660 startingPage "1251" @default.
• W2074728660 abstract "Synaptic transmission is characterized by a remarkable trial-to-trial variability in the postsynaptic response, influencing the way in which information is processed in neuronal networks. This variability may originate from the probabilistic nature of quantal transmitter release, from the stochastic behavior of the receptors, or from the fluctuation of the transmitter concentration in the cleft. We combined nonstationary noise analysis and modeling techniques to estimate the contribution of transmitter fluctuation to miniature inhibitory postsynaptic current (mIPSC) variability. A substantial variability (∼30%) in mIPSC decay was found in all cell types studied (neocortical layer2/3 pyramidal cells, granule cells of the olfactory bulb, and interneurons of the cerebellar molecular layer). This large variability was not solely the consequence of the expression of multiple types of GABAA receptors, as a similar mIPSC decay variability was observed in cerebellar interneurons that express only a single type (α1β2γ2) of GABAA receptor. At large synapses on these cells, all variance in mIPSC decay could be accounted for by the stochastic behavior of ∼36 pS channels, consistent with the conductance of α1β2γ2 GABAA receptors at physiological temperatures. In contrast, at small synapses, a significant amount of variability in the synaptic cleft GABA transient had to be present to account for the additional variance in IPSC decay over that produced by stochastic channel openings. Thus, our results suggest a synapse-specific contribution of the variation of the spatiotemporal profile of GABA to the decay of IPSCs." @default.
• W2074728660 created "2016-06-24" @default.
• W2074728660 creator A5017700541 @default.
• W2074728660 creator A5049577242 @default.
• W2074728660 creator A5065179137 @default.
• W2074728660 date "2001-03-01" @default.
• W2074728660 modified "2023-10-12" @default.
• W2074728660 title "Synapse-Specific Contribution of the Variation of Transmitter Concentration to the Decay of Inhibitory Postsynaptic Currents" @default.
• W2074728660 cites W1480770914 @default.
• W2074728660 cites W1524203275 @default.
• W2074728660 cites W1670909519 @default.
• W2074728660 cites W1710559804 @default.
• W2074728660 cites W1784467576 @default.
• W2074728660 cites W1798308120 @default.
• W2074728660 cites W1878427780 @default.
• W2074728660 cites W1899588485 @default.
• W2074728660 cites W1932887997 @default.
• W2074728660 cites W1967192722 @default.
• W2074728660 cites W1969088446 @default.
• W2074728660 cites W1970953072 @default.
• W2074728660 cites W1978181170 @default.
• W2074728660 cites W1982860158 @default.
• W2074728660 cites W1985220401 @default.
• W2074728660 cites W1997425969 @default.
• W2074728660 cites W2002287054 @default.
• W2074728660 cites W2003059369 @default.
• W2074728660 cites W2007443737 @default.
• W2074728660 cites W2008964647 @default.
• W2074728660 cites W2008967473 @default.
• W2074728660 cites W2015290558 @default.
• W2074728660 cites W2023459285 @default.
• W2074728660 cites W2028918005 @default.
• W2074728660 cites W2030201784 @default.
• W2074728660 cites W2031872972 @default.
• W2074728660 cites W2037485952 @default.
• W2074728660 cites W2038556096 @default.
• W2074728660 cites W2039738625 @default.
• W2074728660 cites W2043385322 @default.
• W2074728660 cites W2065188087 @default.
• W2074728660 cites W2066562577 @default.
• W2074728660 cites W2068435366 @default.
• W2074728660 cites W2069362932 @default.
• W2074728660 cites W2072962057 @default.
• W2074728660 cites W2074990246 @default.
• W2074728660 cites W2076256595 @default.
• W2074728660 cites W2079428986 @default.
• W2074728660 cites W2096226203 @default.
• W2074728660 cites W2105829350 @default.
• W2074728660 cites W2106081526 @default.
• W2074728660 cites W2111091144 @default.
• W2074728660 cites W2128806021 @default.
• W2074728660 cites W2134343364 @default.
• W2074728660 cites W2136115516 @default.
• W2074728660 cites W2146123767 @default.
• W2074728660 cites W2165062318 @default.
• W2074728660 cites W2171788395 @default.
• W2074728660 cites W2299687596 @default.
• W2074728660 cites W4240737082 @default.
• W2074728660 doi "https://doi.org/10.1016/s0006-3495(01)76101-2" @default.
• W2074728660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1301320" @default.
• W2074728660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11222289" @default.
• W2074728660 hasPublicationYear "2001" @default.
• W2074728660 type Work @default.
• W2074728660 sameAs 2074728660 @default.
• W2074728660 citedByCount "95" @default.
• W2074728660 countsByYear W20747286602012 @default.
• W2074728660 countsByYear W20747286602013 @default.
• W2074728660 countsByYear W20747286602014 @default.
• W2074728660 countsByYear W20747286602015 @default.
• W2074728660 countsByYear W20747286602016 @default.
• W2074728660 countsByYear W20747286602017 @default.
• W2074728660 countsByYear W20747286602018 @default.
• W2074728660 countsByYear W20747286602021 @default.
• W2074728660 countsByYear W20747286602023 @default.
• W2074728660 crossrefType "journal-article" @default.
• W2074728660 hasAuthorship W2074728660A5017700541 @default.
• W2074728660 hasAuthorship W2074728660A5049577242 @default.
• W2074728660 hasAuthorship W2074728660A5065179137 @default.
• W2074728660 hasBestOaLocation W20747286601 @default.
• W2074728660 hasConcept C112592302 @default.
• W2074728660 hasConcept C12554922 @default.
• W2074728660 hasConcept C127445978 @default.
• W2074728660 hasConcept C168258287 @default.
• W2074728660 hasConcept C169760540 @default.
• W2074728660 hasConcept C170493617 @default.
• W2074728660 hasConcept C17077164 @default.
• W2074728660 hasConcept C185592680 @default.
• W2074728660 hasConcept C197341189 @default.
• W2074728660 hasConcept C200170125 @default.
• W2074728660 hasConcept C2776464000 @default.
• W2074728660 hasConcept C2778888523 @default.
• W2074728660 hasConcept C2780496858 @default.
• W2074728660 hasConcept C2910581834 @default.
• W2074728660 hasConcept C529278444 @default.
• W2074728660 hasConcept C55493867 @default.
• W2074728660 hasConcept C86803240 @default.
• W2074728660 hasConceptScore W2074728660C112592302 @default.
• W2074728660 hasConceptScore W2074728660C12554922 @default.

• next