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• W2074734213 abstract "Purpose Altered proteasome functions are associated with multiple cardiomyopathies. While the proteasome targets polyubiquitinated proteins for destruction, it itself is modifiable by ubiquitination. We aim to identify the exact ubiquitination sites on cardiac proteasomes and examine whether they are also subject to acetylations. Experimental design Assembled cardiac 20S proteasome complexes were purified from five human hearts with ischemic cardiomyopathy, then analyzed by high-resolution MS to identify ubiquitination and acetylation sites. We developed a library search strategy that may be used to complement database search in identifying PTM in different samples. Results We identified 63 ubiquitinated lysines from intact human cardiac 20S proteasomes. In parallel, 65 acetylated residues were also discovered, 39 of which shared with ubiquitination sites. Conclusion and clinical relevance This is the most comprehensive characterization of cardiac proteasome ubiquitination to date. There are significant overlaps between the discovered ubiquitination and acetylation sites, permitting potential crosstalk in regulating proteasome functions. The information presented here will aid future therapeutic strategies aimed at regulating the functions of cardiac proteasomes." @default.
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• W2074734213 date "2014-08-01" @default.
• W2074734213 modified "2023-10-13" @default.
• W2074734213 title "Lysine ubiquitination and acetylation of human cardiac 20S proteasomes" @default.
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• W2074734213 doi "https://doi.org/10.1002/prca.201400029" @default.
• W2074734213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5094860" @default.
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