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• W2074734885 endingPage "893" @default.
• W2074734885 startingPage "883" @default.
• W2074734885 abstract "According to a previous restriction nuclease analysis, bovine 1.706 satellite DNA (density 1.706 g/cm3 in CsCl) is organized in an unusual structure of superimposed long- and short-range repeats (Streeck and Zachau, 1978). We have now determined the nucleotide sequence of this satellite DNA in both cloned fragments and fragments from the total satellite DNA. Each long-range repeat unit (about 2350 bp) is divided into four segments. Each segment consists of different variants of a basic 23 bp sequence which is itself composed of a dodecanucleotide and a related undecanucleotide. A total of 2400 nucleotides have been sequenced. Detailed analysis of the sequence divergence reveals that both the overall extent of divergence and the frequency of base changes at individual positions of the 23 bp repeats are characteristically different in the various segments. Preferentially methylated sites and a high incidence of symmetry elements are found. In two of the four segments, 22 of 23 bp of the prototype sequence are included in six overlapping elements of dyad symmetry and in a palindrome. A scheme for the evolution of the satellite DNA from a basic dodecanucleotide is proposed which is based on the different degrees of divergence for the various repeats superimposed in this satellite DNA." @default.
• W2074734885 created "2016-06-24" @default.
• W2074734885 creator A5008807676 @default.
• W2074734885 creator A5049987132 @default.
• W2074734885 creator A5062444986 @default.
• W2074734885 date "1979-11-01" @default.
• W2074734885 modified "2023-09-26" @default.
• W2074734885 title "Patchwork structure of a bovine satellite DNA" @default.
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• W2074734885 doi "https://doi.org/10.1016/0092-8674(79)90140-5" @default.
• W2074734885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/519761" @default.
• W2074734885 hasPublicationYear "1979" @default.
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