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- W2074735277 abstract "Pancreatic adenocarcinoma displays a variety of molecular changes that evolve exponentially with time and lead cancer cells not only to survive, but also to invade the surrounding tissues and metastasise to distant sites. These changes include: genetic alterations in oncogenes and cancer suppressor genes; changes in the cell cycle and pathways leading to apoptosis; and also changes in epithelial to mesenchymal transition. The most common alterations involve the epidermal growth factor receptor (EGFR) gene, the HER2 gene, and the K-ras gene. In particular, the loss of function of tumor-suppressor genes has been documented in this tumor, especially in CDKN2a, p53, DPC4 and BRCA2 genes. However, other molecular events involved in pancreatic adenocarcinoma pathogenesis contribute to its development and maintenance, specifically epigenetic events. In fact, key tumor suppressors that are well established to play a role in pancreatic adenocarcinoma may be altered through hypermethylation, and oncogenes can be upregulated secondary to permissive histone modifications. Indeed, factors involved in tumor invasiveness can be aberrantly expressed through dysregulated microRNAs. This review summarizes current knowledge of pancreatic carcinogenesis from its initiation within a normal cell until the time that it has disseminated to distant organs. In this scenario, highlighting these molecular alterations could provide new clinical tools for early diagnosis and new effective therapies for this malignancy." @default.
- W2074735277 created "2016-06-24" @default.
- W2074735277 creator A5003507376 @default.
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- W2074735277 date "2013-09-30" @default.
- W2074735277 modified "2023-10-14" @default.
- W2074735277 title "Carcinogenesis of Pancreatic Adenocarcinoma: Precursor Lesions" @default.
- W2074735277 cites W1497406478 @default.
- W2074735277 cites W1520001135 @default.
- W2074735277 cites W1525531613 @default.
- W2074735277 cites W1544246953 @default.
- W2074735277 cites W1963505140 @default.
- W2074735277 cites W1964064067 @default.
- W2074735277 cites W1964081206 @default.
- W2074735277 cites W1965281877 @default.
- W2074735277 cites W1965863363 @default.
- W2074735277 cites W1966973445 @default.
- W2074735277 cites W1966981147 @default.
- W2074735277 cites W1969875009 @default.
- W2074735277 cites W1970845320 @default.
- W2074735277 cites W1971852262 @default.
- W2074735277 cites W1974767695 @default.
- W2074735277 cites W1976686103 @default.
- W2074735277 cites W1977075884 @default.
- W2074735277 cites W1978148663 @default.
- W2074735277 cites W1978683990 @default.
- W2074735277 cites W1979098619 @default.
- W2074735277 cites W1980741832 @default.
- W2074735277 cites W1981477203 @default.
- W2074735277 cites W1984676170 @default.
- W2074735277 cites W1984879115 @default.
- W2074735277 cites W1989732890 @default.
- W2074735277 cites W1992995822 @default.
- W2074735277 cites W1993421464 @default.
- W2074735277 cites W1994686298 @default.
- W2074735277 cites W1997233622 @default.
- W2074735277 cites W1998154281 @default.
- W2074735277 cites W2001868613 @default.
- W2074735277 cites W2002355858 @default.
- W2074735277 cites W2002689737 @default.
- W2074735277 cites W2006797972 @default.
- W2074735277 cites W2008945738 @default.
- W2074735277 cites W2009629707 @default.
- W2074735277 cites W2009640362 @default.
- W2074735277 cites W2009973750 @default.
- W2074735277 cites W2011181841 @default.
- W2074735277 cites W2011550114 @default.
- W2074735277 cites W2011807945 @default.
- W2074735277 cites W2012084975 @default.
- W2074735277 cites W2014946489 @default.
- W2074735277 cites W2017840637 @default.
- W2074735277 cites W2020080445 @default.
- W2074735277 cites W2022195700 @default.
- W2074735277 cites W2023755253 @default.
- W2074735277 cites W2024974524 @default.
- W2074735277 cites W2026468262 @default.
- W2074735277 cites W2027127452 @default.
- W2074735277 cites W2028835259 @default.
- W2074735277 cites W2029665800 @default.
- W2074735277 cites W2030106400 @default.
- W2074735277 cites W2030199762 @default.
- W2074735277 cites W2031280625 @default.
- W2074735277 cites W2031586352 @default.
- W2074735277 cites W2033329729 @default.
- W2074735277 cites W2033406275 @default.
- W2074735277 cites W2034753993 @default.
- W2074735277 cites W2035063127 @default.
- W2074735277 cites W2035704783 @default.
- W2074735277 cites W2035987476 @default.
- W2074735277 cites W2036802163 @default.
- W2074735277 cites W2037905223 @default.
- W2074735277 cites W2041234310 @default.
- W2074735277 cites W2044801655 @default.
- W2074735277 cites W2045475719 @default.
- W2074735277 cites W2046577405 @default.
- W2074735277 cites W2046709996 @default.
- W2074735277 cites W2049579872 @default.
- W2074735277 cites W2053375200 @default.
- W2074735277 cites W2054041390 @default.
- W2074735277 cites W2054523619 @default.
- W2074735277 cites W2055797019 @default.
- W2074735277 cites W2056390134 @default.
- W2074735277 cites W2056494524 @default.
- W2074735277 cites W2056646351 @default.
- W2074735277 cites W2058956351 @default.
- W2074735277 cites W2060642917 @default.
- W2074735277 cites W2061876263 @default.
- W2074735277 cites W2067072464 @default.
- W2074735277 cites W2070338369 @default.