FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074740400> ?p ?o ?g. }

• W2074740400 endingPage "319" @default.
• W2074740400 startingPage "313" @default.
• W2074740400 abstract "Hca-P and Hca-F is a pair of synogenetic mouse hepatocarcinoma ascites cell lines, possessing different capacity of lymphatic metastasis. Receptor of activated C-kinase 1 (Rack1), together with Jnk1 and gelsolin (Gsn) were previously identified as differentially expressed proteins for lymphatic metastatic potential between the two cell lines. As an intracellular scaffold protein, Rack1 could recruit such signaling molecules as integrins, Src, PKC which are involved in many important biological processes and play key roles in cancer progression. In our present studies, pCDNA3.1(+)-Rack1, a eukaryotic expression plasmid, was constructed and stably transfected into Hca-P cells with a low metastatic potential. CCK8 assay and transwell system were used to evaluate the effects of Rack1 on proliferation, migration and invasion of Hca-P cells in vitro. Then, LY294002, an inhibitor of PI3K, was added into the culture medium of pCDNA3.1(+)-Rack1-Hca-P cells and their biological behaviors observed further. Moreover, the expression of Jnk1, Rac1 and Gsn of pCDNA3.1(+)-Rack1-Hca-P cells were detected by western blot after pretreated with various doses of LY294002. As a result, the proliferation, migration and invasion of pCDNA3.1(+)-Rack1-Hca-P cells were significantly enhanced and could be inhibited by LY294002. In addition, the expression of Gsn, Rac1 and Jnk1 of pCDNA3.1(+)-Rack1-Hca-P cells also decreased after pretreated with LY294002. The expression of Gsn can be inhibited by NSC33766 (an inhibitor of Rac1). Taken together, Rack1/PI3K/Rac1 signaling pathway may play a crucial role in malignant biological behaviors of mouse hepatocarcinoma cells with lymphatic metastasis potential. It may be a potential target for therapy of cancer lymphatic metastasis." @default.
• W2074740400 created "2016-06-24" @default.
• W2074740400 creator A5023009425 @default.
• W2074740400 creator A5033054114 @default.
• W2074740400 creator A5038407194 @default.
• W2074740400 creator A5048951968 @default.
• W2074740400 creator A5056168495 @default.
• W2074740400 creator A5067967993 @default.
• W2074740400 creator A5071672663 @default.
• W2074740400 creator A5088070480 @default.
• W2074740400 creator A5088486032 @default.
• W2074740400 creator A5090242706 @default.
• W2074740400 date "2013-05-01" @default.
• W2074740400 modified "2023-10-14" @default.
• W2074740400 title "RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway" @default.
• W2074740400 cites W1965319787 @default.
• W2074740400 cites W1973871159 @default.
• W2074740400 cites W1975969061 @default.
• W2074740400 cites W1980973069 @default.
• W2074740400 cites W1981711832 @default.
• W2074740400 cites W1983065127 @default.
• W2074740400 cites W1983687466 @default.
• W2074740400 cites W1990905826 @default.
• W2074740400 cites W1991714532 @default.
• W2074740400 cites W1993878658 @default.
• W2074740400 cites W1994636787 @default.
• W2074740400 cites W1998123229 @default.
• W2074740400 cites W2008382887 @default.
• W2074740400 cites W2009886463 @default.
• W2074740400 cites W2030953851 @default.
• W2074740400 cites W2055915895 @default.
• W2074740400 cites W2066509081 @default.
• W2074740400 cites W2077565781 @default.
• W2074740400 cites W2085002181 @default.
• W2074740400 cites W2096625099 @default.
• W2074740400 cites W2114860864 @default.
• W2074740400 cites W2126834741 @default.
• W2074740400 cites W2133915882 @default.
• W2074740400 cites W2136166556 @default.
• W2074740400 cites W2141846114 @default.
• W2074740400 cites W2149364554 @default.
• W2074740400 cites W2157983485 @default.
• W2074740400 cites W2160332942 @default.
• W2074740400 cites W2170513984 @default.
• W2074740400 cites W2172276655 @default.
• W2074740400 cites W272214562 @default.
• W2074740400 doi "https://doi.org/10.1016/j.biopha.2013.01.011" @default.
• W2074740400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23582786" @default.
• W2074740400 hasPublicationYear "2013" @default.
• W2074740400 type Work @default.
• W2074740400 sameAs 2074740400 @default.
• W2074740400 citedByCount "38" @default.
• W2074740400 countsByYear W20747404002013 @default.
• W2074740400 countsByYear W20747404002014 @default.
• W2074740400 countsByYear W20747404002015 @default.
• W2074740400 countsByYear W20747404002016 @default.
• W2074740400 countsByYear W20747404002017 @default.
• W2074740400 countsByYear W20747404002019 @default.
• W2074740400 countsByYear W20747404002020 @default.
• W2074740400 countsByYear W20747404002021 @default.
• W2074740400 countsByYear W20747404002022 @default.
• W2074740400 crossrefType "journal-article" @default.
• W2074740400 hasAuthorship W2074740400A5023009425 @default.
• W2074740400 hasAuthorship W2074740400A5033054114 @default.
• W2074740400 hasAuthorship W2074740400A5038407194 @default.
• W2074740400 hasAuthorship W2074740400A5048951968 @default.
• W2074740400 hasAuthorship W2074740400A5056168495 @default.
• W2074740400 hasAuthorship W2074740400A5067967993 @default.
• W2074740400 hasAuthorship W2074740400A5071672663 @default.
• W2074740400 hasAuthorship W2074740400A5088070480 @default.
• W2074740400 hasAuthorship W2074740400A5088486032 @default.
• W2074740400 hasAuthorship W2074740400A5090242706 @default.
• W2074740400 hasConcept C125705527 @default.
• W2074740400 hasConcept C142669718 @default.
• W2074740400 hasConcept C1491633281 @default.
• W2074740400 hasConcept C153911025 @default.
• W2074740400 hasConcept C185592680 @default.
• W2074740400 hasConcept C2776912716 @default.
• W2074740400 hasConcept C2778308172 @default.
• W2074740400 hasConcept C2779717556 @default.
• W2074740400 hasConcept C38676607 @default.
• W2074740400 hasConcept C502942594 @default.
• W2074740400 hasConcept C54009773 @default.
• W2074740400 hasConcept C54355233 @default.
• W2074740400 hasConcept C55493867 @default.
• W2074740400 hasConcept C62112901 @default.
• W2074740400 hasConcept C62478195 @default.
• W2074740400 hasConcept C80722340 @default.
• W2074740400 hasConcept C81885089 @default.
• W2074740400 hasConcept C86554907 @default.
• W2074740400 hasConcept C86803240 @default.
• W2074740400 hasConcept C95444343 @default.
• W2074740400 hasConceptScore W2074740400C125705527 @default.
• W2074740400 hasConceptScore W2074740400C142669718 @default.
• W2074740400 hasConceptScore W2074740400C1491633281 @default.
• W2074740400 hasConceptScore W2074740400C153911025 @default.
• W2074740400 hasConceptScore W2074740400C185592680 @default.
• W2074740400 hasConceptScore W2074740400C2776912716 @default.

• next