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- W2074751330 abstract "Active cellular locomotion is a feature of such diverse cell types as lymphocytes and cancer cells. The locomotory phenotype of a cell should ultimately reflect the biochemical basis of different migratory strategies. We investigated the locomotory behavior of five epithelial cell lines and one non-epithelial human cell-line as well as human CD4+ T lymphocytes in a three-dimensional collagen type I matrix using time-lapse video microscopy and computer assisted cell-tracking. Migration velocity was up to 70 times lower in tumor cells (0.1–0.3 μm/min) as compared to T lymphocytes (7–7.5 μm/min), whereas the percentage of spontaneously active cells was up to twice as high in tumor cells (80–90%) in comparison to T lymphocytes (54%). Persistence, i.e. the degree of roaming, varied appreciably between the different cell types. In conclusion, velocity and persistence may describe distinct migration strategies in different cell types, i.e. discerning T cell migration from tumor cell invasion." @default.
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- W2074751330 date "1997-10-01" @default.
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- W2074751330 title "Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice" @default.
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- W2074751330 doi "https://doi.org/10.1016/s0304-3835(97)00328-5" @default.
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