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• W2074752739 abstract "Growth of human promonocytic leukaemic U937 cells was found arrested within 24 h upon exposure to interferon gamma (IFN-gamma). Removal of the interferon did not result in the resumption of growth, as is evident from the absence of doubling of viable cell count and(3)H-thymidine incorporation. 5-Bromo-2'-deoxyuridine-based flow cytometric analysis of the growth-arrested cells, 24 h subsequent to the removal of IFN-gamma, showed absence of DNA synthesis, confirming the irreversible nature of the growth inhibition. Propidium iodide-based flow cytometric analysis of the growth-arrested cells showed a distribution which is typical of a growth inhibition without resulting in the accumulation of cells in any specific phase of the cell cycle. These results indicated that IFN-gamma arrested growth of U937 cells in an irreversible and cell cycle phase-independent manner. These observations were in contrast to our earlier report on the reversible and cell cycle phase-specific growth inhibition of human amniotic (fetal epithelial) WISH cells by the interferon." @default.
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• W2074752739 date "1999-09-01" @default.
• W2074752739 modified "2023-09-26" @default.
• W2074752739 title "GROWTH INHIBITION OF HUMAN PROMONOCYTIC LEUKAEMIC U937 CELLS BY INTERFERON GAMMA IS IRREVERSIBLE AND NOT CELL CYCLE PHASE-SPECIFIC" @default.
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• W2074752739 doi "https://doi.org/10.1006/cyto.1998.0474" @default.
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