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- W2074759063 abstract "We have previously shown that social confrontation between aggressive fish (e.g., Tilapia) produces a suppression of several immunological parameters--nonspecific cytotoxicity and mitogen-stimulated proliferation in pronephric leukocytes--in the subordinate fish. By using the opioid antagonist, naltrexone, we now demonstrate indirectly that this immunosuppression is in part mediated by the endogenous opioid system. Evidence is presented that naltrexone-mediated reversal of immunosuppression may be limited to the populations of the cytotoxic and T-cell lineages. The proliferation response to lipopolysaccharide is unaffected by naltrexone. Our data also demonstrate that serum from subordinate (immunosuppressed) fish is immunosuppressive in normal fish--an effect that can be reversed by naltrexone. These results support a link between the neuroendocrine and immune systems in fish, the lowest vertebrate." @default.
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- W2074759063 date "1989-09-01" @default.
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- W2074759063 title "Social confrontation “Stress” in aggressive fish is associated with an endogenous opioid-mediated suppression of proliferative response to mitogens and nonspecific cytotoxicity" @default.
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- W2074759063 doi "https://doi.org/10.1016/0889-1591(89)90038-x" @default.
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