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- W2074760802 abstract "Abstract The hydrolysis of isocarboxazid, a monoamine oxidase inhibitor, by rat liver homogenate was inhibited after treatment of rats with EPN at doses below those which inhibited serum cholinesterase. After single doses of EPN (5–15 mg/kg), almost complete inhibition of isocarboxazid amidase occurred sooner, and persisted longer, than cholinesterase inhibition. Tissue monoamine oxidase inhibition by isocarboxazid was reduced by pretreatment with EPN in rats. Administration of EPN for 3 consecutive days at lower doses (0.5–2.5 mg/kg) caused no inhibition of cholinesterase but produced a small, consistent, inhibition of liver isocarboxazid amidase. In this study the liver isocarboxazid amidase was shown to be a more sensitive indicator of exposure to EPN intoxication than serum cholinesterase inhibition." @default.
- W2074760802 created "2016-06-24" @default.
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- W2074760802 date "1973-08-01" @default.
- W2074760802 modified "2023-10-16" @default.
- W2074760802 title "Comparative studies on the inhibition of liver amidases, aminopeptidase and serum cholinesterases by EPN" @default.
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- W2074760802 doi "https://doi.org/10.1016/0041-008x(73)90024-0" @default.
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