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- W2074769504 endingPage "16" @default.
- W2074769504 startingPage "10" @default.
- W2074769504 abstract "Fatigue represents a common side effect of several drugs, however, the underlying mechanisms have not been well identified. A depression of the central nervous system (CNS) and/or changes in peripheral processes have been associated with the development of fatigue. Antiepileptic drugs (AEDs), generally decreasing CNS excitability, are used in the treatment of seizures as well as other neurological and psychiatric diseases. Fatigue is certainly a common AEDs' side effect, although a high degree of variability exists depending on both patients' characteristics and the drug used. Here, we delineate the pathophysiological central and peripheral mechanisms by which AEDs may cause fatigue also reviewing the available clinical data in order to assess a possible AEDs rank and highlight each AEDs related risk. It appears that drugs acting on the GABAergic system have the highest incidence (with tiagabine exception) of fatigue followed by Gabapentin and Levetiracetam whereas drugs mainly inhibiting sodium channels (Carbamazepine, Eslicarbazepine, Lamotrigine, Phenytoin and Valproate) have the lowest. However, the dose used, AEDs related side effects and patients' characteristics might influence the degree of fatigue observed." @default.
- W2074769504 created "2016-06-24" @default.
- W2074769504 creator A5008045147 @default.
- W2074769504 creator A5021378346 @default.
- W2074769504 creator A5049665672 @default.
- W2074769504 creator A5049966462 @default.
- W2074769504 date "2013-10-01" @default.
- W2074769504 modified "2023-09-26" @default.
- W2074769504 title "A review on antiepileptic drugs-dependent fatigue: Pathophysiological mechanisms and incidence" @default.
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- W2074769504 doi "https://doi.org/10.1016/j.ejphar.2013.09.013" @default.