Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074771844> ?p ?o ?g. }
- W2074771844 endingPage "H2152" @default.
- W2074771844 startingPage "H2144" @default.
- W2074771844 abstract "Studies in streptozotocin (STZ)-induced diabetic rats have demonstrated cardiovascular abnormalities such as depressed mean arterial blood pressure (MABP) and heart rate (HR), endothelial dysfunction, and attenuated pressor responses to vasoactive agents. We investigated whether these abnormalities are due to diabetes-associated activation of inducible nitric oxide synthase (iNOS). In addition, the effect of the duration of diabetes on these abnormalities was also evaluated. Diabetes was induced by administration of 60 mg/kg STZ via the tail vein. One, 3, 9, or 12 wk after STZ injection, MABP, HR, and endothelial function were measured in conscious unrestrained rats. Pressor response curves to bolus doses of methoxamine (MTX) and angiotensin II (ANG II) were constructed in the presence of N-[3(aminomethyl)benzyl]-acetamidine, dihydrochloride (1400W), a specific inhibitor of iNOS. Depressed MABP and HR and impairment of endothelial function were observed as early as 3 wk after induction of diabetes. Acute inhibition of iNOS with 1400W (3 mg/kg iv) restored the attenuated pressor responses to both MTX and ANG II without affecting the basal MABP and HR. Immunohistochemical and Western analysis blot studies in cardiovascular tissues revealed decreased expression of endothelial nitric oxide synthase (eNOS) concomitant with increased expression of iNOS and nitrotyrosine with the progression of diabetes. Our findings suggest that induction of iNOS in cardiovascular tissues is dependent on the duration of diabetes and contributes significantly to the depressed pressor responses to vasoactive agents and potentially to endothelial dysfunction." @default.
- W2074771844 created "2016-06-24" @default.
- W2074771844 creator A5005253705 @default.
- W2074771844 creator A5060070593 @default.
- W2074771844 creator A5071051054 @default.
- W2074771844 creator A5086814411 @default.
- W2074771844 date "2005-11-01" @default.
- W2074771844 modified "2023-10-17" @default.
- W2074771844 title "Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes" @default.
- W2074771844 cites W1542671396 @default.
- W2074771844 cites W1572056633 @default.
- W2074771844 cites W1751292602 @default.
- W2074771844 cites W1975861856 @default.
- W2074771844 cites W1986063858 @default.
- W2074771844 cites W1993889769 @default.
- W2074771844 cites W2007469818 @default.
- W2074771844 cites W2020436830 @default.
- W2074771844 cites W2022939284 @default.
- W2074771844 cites W2025257459 @default.
- W2074771844 cites W2027471608 @default.
- W2074771844 cites W2034535733 @default.
- W2074771844 cites W2038727041 @default.
- W2074771844 cites W2052391094 @default.
- W2074771844 cites W2066808044 @default.
- W2074771844 cites W2068120257 @default.
- W2074771844 cites W2069430994 @default.
- W2074771844 cites W2069822765 @default.
- W2074771844 cites W2070438395 @default.
- W2074771844 cites W2071654144 @default.
- W2074771844 cites W2074185335 @default.
- W2074771844 cites W2076708176 @default.
- W2074771844 cites W2081905245 @default.
- W2074771844 cites W2085194502 @default.
- W2074771844 cites W2088971354 @default.
- W2074771844 cites W2091238544 @default.
- W2074771844 cites W2103445279 @default.
- W2074771844 cites W2113395236 @default.
- W2074771844 cites W2119914564 @default.
- W2074771844 cites W2132933056 @default.
- W2074771844 cites W2135156382 @default.
- W2074771844 cites W2138441199 @default.
- W2074771844 cites W2143545640 @default.
- W2074771844 cites W2150693826 @default.
- W2074771844 cites W2151219965 @default.
- W2074771844 cites W2169061609 @default.
- W2074771844 cites W2288016020 @default.
- W2074771844 cites W2326665702 @default.
- W2074771844 cites W2410168531 @default.
- W2074771844 cites W4293247451 @default.
- W2074771844 doi "https://doi.org/10.1152/ajpheart.00591.2005" @default.
- W2074771844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16006542" @default.
- W2074771844 hasPublicationYear "2005" @default.
- W2074771844 type Work @default.
- W2074771844 sameAs 2074771844 @default.
- W2074771844 citedByCount "137" @default.
- W2074771844 countsByYear W20747718442012 @default.
- W2074771844 countsByYear W20747718442013 @default.
- W2074771844 countsByYear W20747718442014 @default.
- W2074771844 countsByYear W20747718442015 @default.
- W2074771844 countsByYear W20747718442016 @default.
- W2074771844 countsByYear W20747718442017 @default.
- W2074771844 countsByYear W20747718442018 @default.
- W2074771844 countsByYear W20747718442019 @default.
- W2074771844 countsByYear W20747718442020 @default.
- W2074771844 countsByYear W20747718442021 @default.
- W2074771844 countsByYear W20747718442022 @default.
- W2074771844 countsByYear W20747718442023 @default.
- W2074771844 crossrefType "journal-article" @default.
- W2074771844 hasAuthorship W2074771844A5005253705 @default.
- W2074771844 hasAuthorship W2074771844A5060070593 @default.
- W2074771844 hasAuthorship W2074771844A5071051054 @default.
- W2074771844 hasAuthorship W2074771844A5086814411 @default.
- W2074771844 hasConcept C126322002 @default.
- W2074771844 hasConcept C134018914 @default.
- W2074771844 hasConcept C2777622882 @default.
- W2074771844 hasConcept C2778326061 @default.
- W2074771844 hasConcept C2779280383 @default.
- W2074771844 hasConcept C2780972559 @default.
- W2074771844 hasConcept C2908929049 @default.
- W2074771844 hasConcept C519581460 @default.
- W2074771844 hasConcept C555293320 @default.
- W2074771844 hasConcept C71924100 @default.
- W2074771844 hasConcept C84393581 @default.
- W2074771844 hasConceptScore W2074771844C126322002 @default.
- W2074771844 hasConceptScore W2074771844C134018914 @default.
- W2074771844 hasConceptScore W2074771844C2777622882 @default.
- W2074771844 hasConceptScore W2074771844C2778326061 @default.
- W2074771844 hasConceptScore W2074771844C2779280383 @default.
- W2074771844 hasConceptScore W2074771844C2780972559 @default.
- W2074771844 hasConceptScore W2074771844C2908929049 @default.
- W2074771844 hasConceptScore W2074771844C519581460 @default.
- W2074771844 hasConceptScore W2074771844C555293320 @default.
- W2074771844 hasConceptScore W2074771844C71924100 @default.
- W2074771844 hasConceptScore W2074771844C84393581 @default.
- W2074771844 hasIssue "5" @default.
- W2074771844 hasLocation W20747718441 @default.
- W2074771844 hasLocation W20747718442 @default.
- W2074771844 hasOpenAccess W2074771844 @default.