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- W2074773013 abstract "I am writing in response to the concerns expressed by Dr. Cuestra and colleagues regarding not citing their work in our recently published manuscript. First, I would like to differentiate their work published in The International Journal of Cancer from ours. As found in the first paragraph under the “Discussion” section of our paper, we have pointed out that many researchers used different trimerizing domains, including the C-terminal non-collagenous (NC1) domain of collagens (in the case of Cuestra et al., the NC1 domain of type XVIII collagen; others were derived from the C-propeptide of fibrillar collagens), to drive the trimerization of its fusion partners (antibody fragments, cytokines, growth factors, et al.). In contrast, we adopted a novel approach by using a short self-trimerizing collagen-like peptide to fulfill the art. This was based on the finding of our previous work, in which the formation of the triple-helical structure of type XXI collagen is governed by the C-terminal collagenous (COL1) domain and the content of hydroxyproline in the COL1 is crucial for the collagen trimerization. We did an extensive work focusing on the characterization of the self-trimerizing (GPP)10-scaffold fusion complexes. Due to manuscript size constraints and considering the above distinct mechanisms in terms of promoting antibody fragment trimerization with collagen-derived sequences, we did not emphasize their work in our paper. Nevertheless, I apologize that we did not cite their paper as a reference in the “Discussion” section of our manuscript. I thank Dr. Cuestraand colleagues for their comments and interest in our manuscript." @default.
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- W2074773013 date "2008-10-01" @default.
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- W2074773013 title "Response to: “Comment on ‘Production of multivalent protein binders using a self‐trimerization collagen‐like peptide scaffold’”" @default.
- W2074773013 doi "https://doi.org/10.1096/fj.08-1004ltr" @default.
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