Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074782816> ?p ?o ?g. }
- W2074782816 endingPage "e1000161" @default.
- W2074782816 startingPage "e1000161" @default.
- W2074782816 abstract "Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wide liver expression profiles of mice with those two extremes of lifespan. Contrary to expectation, we find significant, genome-wide expression associations between the progeroid and long-lived mice. Subsequent analysis of significantly over-represented biological processes revealed suppression of the endocrine and energy pathways with increased stress responses in both delayed and premature aging. To test the relevance of these processes in natural aging, we compared the transcriptomes of liver, lung, kidney, and spleen over the entire murine adult lifespan and subsequently confirmed these findings on an independent aging cohort. The majority of genes showed similar expression changes in all four organs, indicating a systemic transcriptional response with aging. This systemic response included the same biological processes that are triggered in progeroid and long-lived mice. However, on a genome-wide scale, transcriptomes of naturally aged mice showed a strong association to progeroid but not to long-lived mice. Thus, endocrine and metabolic changes are indicative of “survival” responses to genotoxic stress or starvation, whereas genome-wide associations in gene expression with natural aging are indicative of biological age, which may thus delineate pro- and anti-aging effects of treatments aimed at health-span extension." @default.
- W2074782816 created "2016-06-24" @default.
- W2074782816 creator A5018886262 @default.
- W2074782816 creator A5031038259 @default.
- W2074782816 creator A5039109863 @default.
- W2074782816 creator A5039341868 @default.
- W2074782816 creator A5043039694 @default.
- W2074782816 creator A5045503519 @default.
- W2074782816 creator A5052209499 @default.
- W2074782816 creator A5062040602 @default.
- W2074782816 creator A5062870063 @default.
- W2074782816 creator A5063101725 @default.
- W2074782816 creator A5066431589 @default.
- W2074782816 creator A5070235735 @default.
- W2074782816 creator A5080863597 @default.
- W2074782816 creator A5083619859 @default.
- W2074782816 creator A5085813010 @default.
- W2074782816 date "2008-08-15" @default.
- W2074782816 modified "2023-10-14" @default.
- W2074782816 title "Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms" @default.
- W2074782816 cites W1523543948 @default.
- W2074782816 cites W1609114247 @default.
- W2074782816 cites W1846661225 @default.
- W2074782816 cites W1967181393 @default.
- W2074782816 cites W1979123830 @default.
- W2074782816 cites W1981148605 @default.
- W2074782816 cites W1985425785 @default.
- W2074782816 cites W2000345849 @default.
- W2074782816 cites W2001750225 @default.
- W2074782816 cites W2007771316 @default.
- W2074782816 cites W2016021819 @default.
- W2074782816 cites W2017567442 @default.
- W2074782816 cites W2017841009 @default.
- W2074782816 cites W2037921221 @default.
- W2074782816 cites W2041198010 @default.
- W2074782816 cites W2049538444 @default.
- W2074782816 cites W2049842278 @default.
- W2074782816 cites W2054059225 @default.
- W2074782816 cites W2055210668 @default.
- W2074782816 cites W2059051391 @default.
- W2074782816 cites W2061684121 @default.
- W2074782816 cites W2061719472 @default.
- W2074782816 cites W2062629127 @default.
- W2074782816 cites W2064557280 @default.
- W2074782816 cites W2069049877 @default.
- W2074782816 cites W2073955086 @default.
- W2074782816 cites W2096136751 @default.
- W2074782816 cites W2107105699 @default.
- W2074782816 cites W2124153237 @default.
- W2074782816 cites W2125840439 @default.
- W2074782816 cites W2127903162 @default.
- W2074782816 cites W2133425142 @default.
- W2074782816 cites W2133469432 @default.
- W2074782816 cites W2140323371 @default.
- W2074782816 cites W2140553751 @default.
- W2074782816 cites W2148685655 @default.
- W2074782816 cites W2151427219 @default.
- W2074782816 cites W2155447972 @default.
- W2074782816 cites W2159979637 @default.
- W2074782816 cites W2164175615 @default.
- W2074782816 doi "https://doi.org/10.1371/journal.pgen.1000161" @default.
- W2074782816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2493043" @default.
- W2074782816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18704162" @default.
- W2074782816 hasPublicationYear "2008" @default.
- W2074782816 type Work @default.
- W2074782816 sameAs 2074782816 @default.
- W2074782816 citedByCount "186" @default.
- W2074782816 countsByYear W20747828162012 @default.
- W2074782816 countsByYear W20747828162013 @default.
- W2074782816 countsByYear W20747828162014 @default.
- W2074782816 countsByYear W20747828162015 @default.
- W2074782816 countsByYear W20747828162016 @default.
- W2074782816 countsByYear W20747828162017 @default.
- W2074782816 countsByYear W20747828162018 @default.
- W2074782816 countsByYear W20747828162019 @default.
- W2074782816 countsByYear W20747828162020 @default.
- W2074782816 countsByYear W20747828162021 @default.
- W2074782816 countsByYear W20747828162022 @default.
- W2074782816 countsByYear W20747828162023 @default.
- W2074782816 crossrefType "journal-article" @default.
- W2074782816 hasAuthorship W2074782816A5018886262 @default.
- W2074782816 hasAuthorship W2074782816A5031038259 @default.
- W2074782816 hasAuthorship W2074782816A5039109863 @default.
- W2074782816 hasAuthorship W2074782816A5039341868 @default.
- W2074782816 hasAuthorship W2074782816A5043039694 @default.
- W2074782816 hasAuthorship W2074782816A5045503519 @default.
- W2074782816 hasAuthorship W2074782816A5052209499 @default.
- W2074782816 hasAuthorship W2074782816A5062040602 @default.
- W2074782816 hasAuthorship W2074782816A5062870063 @default.
- W2074782816 hasAuthorship W2074782816A5063101725 @default.
- W2074782816 hasAuthorship W2074782816A5066431589 @default.
- W2074782816 hasAuthorship W2074782816A5070235735 @default.
- W2074782816 hasAuthorship W2074782816A5080863597 @default.
- W2074782816 hasAuthorship W2074782816A5083619859 @default.
- W2074782816 hasAuthorship W2074782816A5085813010 @default.
- W2074782816 hasBestOaLocation W20747828161 @default.
- W2074782816 hasConcept C104317684 @default.
- W2074782816 hasConcept C106208931 @default.