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• W2074784175 abstract "Pig islets are considered to be most suitable source of islets for xenotransplantation into patients with type 1 diabetes mellitus. However, cellular rejection, especially CD8+ CTL-mediated cytotoxicity, remains a formidable barrier preventing long-term xenograft survival. Our previous study demonstrated that human CD8+ CTLs were highly detrimental to xenograft cells and that this strong cytotoxicity of human CTLs was mediated mainly by the Fas/FasL apoptotic pathway. Furthermore, we exploited novel methods for inhibiting human CD8+ CTL-mediated xenocytotoxicity with overexpression of membrane-bound human FasL and human decoy Fas antigen in xenografted cells. In the present study, we assessed the cytoprotective effects of these novel inhibitory molecules overexpressed by an adenoviral-mediated system in pig islets. Isolated pig islets were transfected with adenovirus vector encoding either human decoy Fas or membrane-bound human FasL genes. Thirty percent to 60% of transfected pig islets expressed these molecules producing 60% to 88% suppression of CTL killing compared with parental pig islets. These data indicated that pig islet grafts isolated from transgenic pigs with either membrane-bound human FasL or human decoy Fas antigen genes may control the innate cellular response to xenografts, and creating a window of opportunity to facilitate xenograft survival." @default.
• W2074784175 created "2016-06-24" @default.
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• W2074784175 date "2006-12-01" @default.
• W2074784175 modified "2023-10-16" @default.
• W2074784175 title "Adenoviral-Mediated Overexpression of Membrane-Bound Human FasL and Human Decoy Fas Protect Pig Islets Against Human CD8+ CTL-Mediated Cytotoxicity" @default.
• W2074784175 cites W1577393853 @default.
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• W2074784175 doi "https://doi.org/10.1016/j.transproceed.2006.10.072" @default.
• W2074784175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17175251" @default.
• W2074784175 hasPublicationYear "2006" @default.
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