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• W2074784328 abstract "We have examined the effects of inhibitors of proton transport systems on osteoclastic bone resorption using an in vitro bone slice assay, where osteoclasts (OCs) are free from the influence of other bone cells. Amiloride (AM) and dimethylamiloride (DMA), inhibitors of the Na+/H+ antiporter, were potent inhibitors of bone resorption (IC50 approximately 9 and 0.7 microM for AM and DMA, respectively). Omeprazole (OM), a potent inhibitor of parietal cell K+/H+(-)ATPase, was a poor inhibitor of OC bone resorption (IC50 approximately 100 microM). These results strongly suggest that the Na+/H+ antiporter is the primary proton system used by OCs during bone resorption." @default.
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• W2074784328 date "1990-02-01" @default.
• W2074784328 modified "2023-10-16" @default.
• W2074784328 title "Na+/H+ antiporter is the primary proton transport system used by osteoclasts during bone resorption" @default.
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• W2074784328 doi "https://doi.org/10.1002/jcp.1041420227" @default.
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