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- W2074799210 abstract "Proteins such as ion channels generally involve specialized mechanisms for optimal interaction with stimulus. Thermal TRP channels are molecular entities in mammals for detection and transduction of temperature among other pain-evoking stimuli. Sensitive detection of temperature by thermal TRP channels is made possible by large enthalpy changes between closed and open states of the channels. Thus, to understand the mechanism of their temperature sensitivity and to properly identify the underlying molecular and structural basis, it is important to have the capability to directly probe the energetics of temperature sensing by these channels. Unfortunately, direct measurement of the energetics of the channels has not been possible; instead they are inferred from functional measurements, typically based on the steepness of temperature dependence of current responses. Since thermal TRP channels are allosteric proteins and the gating convolves multiple steps, such measurements are indirect and have limitations. In this work we tested the idea of using calorimetry to directly probe the energetics of thermal TRP channels. Modern colorimeters have a sensitivity in the range of micro calories, and our experiments suggest that the energetics of thermal TRP channels are within this detectable range. Thus our results support the applicability of calorimetry for direct detection of thermal transitions in thermal TRP channels, and such measurements will be instrumental for understanding and probing properties of temperature sensors, analogous to the use of gating charge measurement for studying voltage-gated channels or binding assays for ligand-gated channels." @default.
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- W2074799210 date "2015-01-01" @default.
- W2074799210 modified "2023-09-30" @default.
- W2074799210 title "Probing Temperature Sensing of Thermal TRP Channels by Calorimetry" @default.
- W2074799210 doi "https://doi.org/10.1016/j.bpj.2014.11.691" @default.
- W2074799210 hasPublicationYear "2015" @default.
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