Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074800204> ?p ?o ?g. }
- W2074800204 endingPage "1753" @default.
- W2074800204 startingPage "1743" @default.
- W2074800204 abstract "Bicyclic amino acids are useful building blocks in synthesizing biologically active molecules and peptidomimetics. 2-Carboxy-6-hydroxyloctahydroindole (Choi) is a novel bicyclic amino acid found in the marine natural products aeruginosins. Many compounds in the aeruginosin family exhibit inhibition activities toward serine proteases including thrombin and trypsin. The unique Choi structure is the common feature of this family of oligopeptides and this motif is important for their observed biological activities. To better understand the influence of the stereochemistry of the Choi core structure on the inhibition activities, we have previously synthesized ring-oxygenated variants from glucose. The preparation of octahydro-pyrano[3,2-b]pyrrole 2-carboxylic acids from d-mannose is reported here. These novel bicyclic amino acids can be used in the preparation of aeruginosin analogs, as well as conformationally constrained peptidomimetics or other biologically active molecules." @default.
- W2074800204 created "2016-06-24" @default.
- W2074800204 creator A5029272162 @default.
- W2074800204 creator A5058176228 @default.
- W2074800204 creator A5082425108 @default.
- W2074800204 date "2008-07-01" @default.
- W2074800204 modified "2023-10-18" @default.
- W2074800204 title "Synthesis of octahydropyrano[3,2-b]pyrrole-2-carboxylic acid derivatives from d-mannose" @default.
- W2074800204 cites W1964418223 @default.
- W2074800204 cites W1967178214 @default.
- W2074800204 cites W1969232987 @default.
- W2074800204 cites W1970433380 @default.
- W2074800204 cites W1971342811 @default.
- W2074800204 cites W1971540757 @default.
- W2074800204 cites W1972577033 @default.
- W2074800204 cites W1973598154 @default.
- W2074800204 cites W1973755249 @default.
- W2074800204 cites W1980505223 @default.
- W2074800204 cites W1982802875 @default.
- W2074800204 cites W1983175741 @default.
- W2074800204 cites W1985581776 @default.
- W2074800204 cites W1989367377 @default.
- W2074800204 cites W1993470980 @default.
- W2074800204 cites W1995119853 @default.
- W2074800204 cites W1996483120 @default.
- W2074800204 cites W2000208080 @default.
- W2074800204 cites W2005892111 @default.
- W2074800204 cites W2021098106 @default.
- W2074800204 cites W2029795762 @default.
- W2074800204 cites W2030221699 @default.
- W2074800204 cites W2034111633 @default.
- W2074800204 cites W2043673855 @default.
- W2074800204 cites W2044910404 @default.
- W2074800204 cites W2052496863 @default.
- W2074800204 cites W2053308358 @default.
- W2074800204 cites W2065957284 @default.
- W2074800204 cites W2068648667 @default.
- W2074800204 cites W2070929861 @default.
- W2074800204 cites W2081701896 @default.
- W2074800204 cites W2085764065 @default.
- W2074800204 cites W2087028668 @default.
- W2074800204 cites W2121747898 @default.
- W2074800204 cites W2144076873 @default.
- W2074800204 cites W2149308753 @default.
- W2074800204 cites W2150360454 @default.
- W2074800204 cites W2176067577 @default.
- W2074800204 cites W2334940563 @default.
- W2074800204 cites W2949767353 @default.
- W2074800204 cites W2950535947 @default.
- W2074800204 cites W2950539162 @default.
- W2074800204 cites W2951161537 @default.
- W2074800204 cites W2951758248 @default.
- W2074800204 cites W2952356300 @default.
- W2074800204 cites W2990245264 @default.
- W2074800204 cites W4362235782 @default.
- W2074800204 doi "https://doi.org/10.1016/j.carres.2008.03.017" @default.
- W2074800204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18433739" @default.
- W2074800204 hasPublicationYear "2008" @default.
- W2074800204 type Work @default.
- W2074800204 sameAs 2074800204 @default.
- W2074800204 citedByCount "12" @default.
- W2074800204 countsByYear W20748002042012 @default.
- W2074800204 countsByYear W20748002042015 @default.
- W2074800204 countsByYear W20748002042016 @default.
- W2074800204 countsByYear W20748002042018 @default.
- W2074800204 countsByYear W20748002042021 @default.
- W2074800204 countsByYear W20748002042023 @default.
- W2074800204 crossrefType "journal-article" @default.
- W2074800204 hasAuthorship W2074800204A5029272162 @default.
- W2074800204 hasAuthorship W2074800204A5058176228 @default.
- W2074800204 hasAuthorship W2074800204A5082425108 @default.
- W2074800204 hasConcept C116073593 @default.
- W2074800204 hasConcept C124790011 @default.
- W2074800204 hasConcept C178790620 @default.
- W2074800204 hasConcept C181199279 @default.
- W2074800204 hasConcept C185592680 @default.
- W2074800204 hasConcept C202751555 @default.
- W2074800204 hasConcept C21951064 @default.
- W2074800204 hasConcept C24961977 @default.
- W2074800204 hasConcept C2775887612 @default.
- W2074800204 hasConcept C2776414213 @default.
- W2074800204 hasConcept C2779281246 @default.
- W2074800204 hasConcept C2779400197 @default.
- W2074800204 hasConcept C515207424 @default.
- W2074800204 hasConcept C55493867 @default.
- W2074800204 hasConcept C71240020 @default.
- W2074800204 hasConceptScore W2074800204C116073593 @default.
- W2074800204 hasConceptScore W2074800204C124790011 @default.
- W2074800204 hasConceptScore W2074800204C178790620 @default.
- W2074800204 hasConceptScore W2074800204C181199279 @default.
- W2074800204 hasConceptScore W2074800204C185592680 @default.
- W2074800204 hasConceptScore W2074800204C202751555 @default.
- W2074800204 hasConceptScore W2074800204C21951064 @default.
- W2074800204 hasConceptScore W2074800204C24961977 @default.
- W2074800204 hasConceptScore W2074800204C2775887612 @default.
- W2074800204 hasConceptScore W2074800204C2776414213 @default.
- W2074800204 hasConceptScore W2074800204C2779281246 @default.
- W2074800204 hasConceptScore W2074800204C2779400197 @default.