FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074802646> ?p ?o ?g. }

• W2074802646 endingPage "27" @default.
• W2074802646 startingPage "23" @default.
• W2074802646 abstract "The polyene antibiotic myxalamide A (1) has been prepared by total synthesis. The synthesis illustrates a useful strategy for synthesis in which the high 1,2-stereocontrol achievable with the aldol reaction can be parlayed by other stereoselective processes so as to give compounds having two or more stereocenters with remote relationships. Application of the Evans asymmetric aldol reaction to aldehyde 13 gives the beta-hydroxy imide 17. Because the substrate is an alpha,beta-unsaturated aldehyde, the alcohol is allylic. After suitable functional group manipulation, this allylic alcohol is subjected to enolate Claisen rearrangement (as propionate 22) to give allylsulfide 23, having three stereocenters with a 1,4,5-relationship. Further functional group manipulation and one-carbon homologation converts this intermediate into 26, which is oxidized and subjected to Evans-Mislow allylsulfoxide rearrangement to obtain 27, having three stereocenters with a 1,2,5-relationship. The synthesis of myxalamide A was completed by converting aldehyde 30 into dienyne 40. Alkyne 40 was hydroborated with catechol borane, and the resulting E-vinylborane was subjected to Suzuki coupling with the Z-iodo triene 9 to provide myxalamide A (1)." @default.
• W2074802646 created "2016-06-24" @default.
• W2074802646 creator A5025194991 @default.
• W2074802646 creator A5089941665 @default.
• W2074802646 date "1998-12-11" @default.
• W2074802646 modified "2023-10-03" @default.
• W2074802646 title "Total Synthesis of Myxalamide A" @default.
• W2074802646 cites W1964261055 @default.
• W2074802646 cites W1964764172 @default.
• W2074802646 cites W1967046486 @default.
• W2074802646 cites W1970484777 @default.
• W2074802646 cites W1981643899 @default.
• W2074802646 cites W1993494102 @default.
• W2074802646 cites W2003227558 @default.
• W2074802646 cites W2005363003 @default.
• W2074802646 cites W2005364245 @default.
• W2074802646 cites W2014775513 @default.
• W2074802646 cites W2023714104 @default.
• W2074802646 cites W2024048388 @default.
• W2074802646 cites W2025823005 @default.
• W2074802646 cites W2026188340 @default.
• W2074802646 cites W2035787945 @default.
• W2074802646 cites W2036871900 @default.
• W2074802646 cites W2039342602 @default.
• W2074802646 cites W2040555832 @default.
• W2074802646 cites W2042547216 @default.
• W2074802646 cites W2044827833 @default.
• W2074802646 cites W2054489385 @default.
• W2074802646 cites W2057055109 @default.
• W2074802646 cites W2059546160 @default.
• W2074802646 cites W2060186192 @default.
• W2074802646 cites W2062435845 @default.
• W2074802646 cites W2066226038 @default.
• W2074802646 cites W2073308447 @default.
• W2074802646 cites W2076760518 @default.
• W2074802646 cites W2078125060 @default.
• W2074802646 cites W2087414071 @default.
• W2074802646 cites W2122389062 @default.
• W2074802646 cites W2344397284 @default.
• W2074802646 cites W2500401755 @default.
• W2074802646 cites W2949204742 @default.
• W2074802646 cites W2949276080 @default.
• W2074802646 cites W2951394729 @default.
• W2074802646 cites W2952275006 @default.
• W2074802646 cites W2952819575 @default.
• W2074802646 cites W3005264824 @default.
• W2074802646 cites W4234573048 @default.
• W2074802646 cites W1966139911 @default.
• W2074802646 doi "https://doi.org/10.1021/jo9813742" @default.
• W2074802646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11674080" @default.
• W2074802646 hasPublicationYear "1998" @default.
• W2074802646 type Work @default.
• W2074802646 sameAs 2074802646 @default.
• W2074802646 citedByCount "67" @default.
• W2074802646 countsByYear W20748026462012 @default.
• W2074802646 countsByYear W20748026462013 @default.
• W2074802646 countsByYear W20748026462014 @default.
• W2074802646 countsByYear W20748026462015 @default.
• W2074802646 countsByYear W20748026462016 @default.
• W2074802646 countsByYear W20748026462017 @default.
• W2074802646 countsByYear W20748026462018 @default.
• W2074802646 countsByYear W20748026462019 @default.
• W2074802646 countsByYear W20748026462020 @default.
• W2074802646 countsByYear W20748026462023 @default.
• W2074802646 crossrefType "journal-article" @default.
• W2074802646 hasAuthorship W2074802646A5025194991 @default.
• W2074802646 hasAuthorship W2074802646A5089941665 @default.
• W2074802646 hasConcept C120095180 @default.
• W2074802646 hasConcept C134195300 @default.
• W2074802646 hasConcept C146686406 @default.
• W2074802646 hasConcept C161790260 @default.
• W2074802646 hasConcept C178790620 @default.
• W2074802646 hasConcept C181647583 @default.
• W2074802646 hasConcept C185592680 @default.
• W2074802646 hasConcept C2777604212 @default.
• W2074802646 hasConcept C2778826510 @default.
• W2074802646 hasConcept C2779594873 @default.
• W2074802646 hasConcept C2779825165 @default.
• W2074802646 hasConcept C2780567667 @default.
• W2074802646 hasConcept C35753019 @default.
• W2074802646 hasConcept C61156836 @default.
• W2074802646 hasConcept C71240020 @default.
• W2074802646 hasConceptScore W2074802646C120095180 @default.
• W2074802646 hasConceptScore W2074802646C134195300 @default.
• W2074802646 hasConceptScore W2074802646C146686406 @default.
• W2074802646 hasConceptScore W2074802646C161790260 @default.
• W2074802646 hasConceptScore W2074802646C178790620 @default.
• W2074802646 hasConceptScore W2074802646C181647583 @default.
• W2074802646 hasConceptScore W2074802646C185592680 @default.
• W2074802646 hasConceptScore W2074802646C2777604212 @default.
• W2074802646 hasConceptScore W2074802646C2778826510 @default.
• W2074802646 hasConceptScore W2074802646C2779594873 @default.
• W2074802646 hasConceptScore W2074802646C2779825165 @default.
• W2074802646 hasConceptScore W2074802646C2780567667 @default.
• W2074802646 hasConceptScore W2074802646C35753019 @default.
• W2074802646 hasConceptScore W2074802646C61156836 @default.
• W2074802646 hasConceptScore W2074802646C71240020 @default.
• W2074802646 hasIssue "1" @default.

• next