FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074805281> ?p ?o ?g. }

• W2074805281 abstract "Natriuretic peptides have been demonstrated to cause relaxation of the human gallbladder muscle through interaction with natriuretic peptide receptor-B (NPR-B/NPR2). Effects of natriuretic peptides in the human esophageal muscle were unknown. To investigate the effects of natriuretic peptides in the human esophagus, we measured relaxation of muscularis mucosae strips isolated from the human esophagus caused by C-type natriuretic peptide (CNP), brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and des[Gln(18), Ser(19), Gly(20), Leu(21), Gly(22)]ANP(4-23) amide (cANP(4-23)), a selective natriuretic peptide receptor-C (NPR-C) agonist. In endothelin-1 or carbachol-contracted mucosal muscle strips, CNP caused moderate, sustained and concentration-dependent relaxation. BNP caused a very mild relaxation whereas ANP and cANP(4-23) did not cause any relaxation. CNP was much more potent than BNP and ANP in causing relaxation. These suggest the existence of NPR-B mediating relaxation. The CNP-induced relaxation was not affected by tetrodotoxin or atropine in endothelin-1-contracted esophageal strips and not by tetrodotoxin in carbachol-contracted strips, indicating a direct effect of CNP on the human esophageal muscularis mucosae. Taken together, these results demonstrate that natriuretic peptides cause relaxation of the muscularis mucosae of the human esophagus and suggest that the relaxation is through interaction with NPR-B. Natriuretic peptides may play an important role in the control of human esophageal motility." @default.
• W2074805281 created "2016-06-24" @default.
• W2074805281 creator A5038467125 @default.
• W2074805281 creator A5056421583 @default.
• W2074805281 date "2008-02-01" @default.
• W2074805281 modified "2023-09-25" @default.
• W2074805281 title "Natriuretic peptides cause relaxation of human esophageal mucosal muscle" @default.
• W2074805281 cites W1843346528 @default.
• W2074805281 cites W1977230495 @default.
• W2074805281 cites W1989621039 @default.
• W2074805281 cites W1994381630 @default.
• W2074805281 cites W2001115693 @default.
• W2074805281 cites W2014889630 @default.
• W2074805281 cites W2020091254 @default.
• W2074805281 cites W2020561947 @default.
• W2074805281 cites W2045076976 @default.
• W2074805281 cites W2045952607 @default.
• W2074805281 cites W2053232655 @default.
• W2074805281 cites W2054649519 @default.
• W2074805281 cites W2056746307 @default.
• W2074805281 cites W2065265905 @default.
• W2074805281 cites W2066725371 @default.
• W2074805281 cites W2070341655 @default.
• W2074805281 cites W2072005678 @default.
• W2074805281 cites W2079854709 @default.
• W2074805281 cites W2081162850 @default.
• W2074805281 cites W2081620568 @default.
• W2074805281 cites W2082400577 @default.
• W2074805281 cites W2086913526 @default.
• W2074805281 cites W2095304387 @default.
• W2074805281 cites W2108255730 @default.
• W2074805281 cites W2120137104 @default.
• W2074805281 cites W2121058501 @default.
• W2074805281 cites W2136592038 @default.
• W2074805281 cites W2152990613 @default.
• W2074805281 cites W2183843875 @default.
• W2074805281 cites W6928553 @default.
• W2074805281 cites W1990348648 @default.
• W2074805281 cites W2018116521 @default.
• W2074805281 doi "https://doi.org/10.1016/j.regpep.2007.09.018" @default.
• W2074805281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17920706" @default.
• W2074805281 hasPublicationYear "2008" @default.
• W2074805281 type Work @default.
• W2074805281 sameAs 2074805281 @default.
• W2074805281 citedByCount "4" @default.
• W2074805281 countsByYear W20748052812015 @default.
• W2074805281 crossrefType "journal-article" @default.
• W2074805281 hasAuthorship W2074805281A5038467125 @default.
• W2074805281 hasAuthorship W2074805281A5056421583 @default.
• W2074805281 hasConcept C126322002 @default.
• W2074805281 hasConcept C134018914 @default.
• W2074805281 hasConcept C170493617 @default.
• W2074805281 hasConcept C185592680 @default.
• W2074805281 hasConcept C2775846464 @default.
• W2074805281 hasConcept C2775915353 @default.
• W2074805281 hasConcept C2776741303 @default.
• W2074805281 hasConcept C2777819096 @default.
• W2074805281 hasConcept C2777960253 @default.
• W2074805281 hasConcept C2778069365 @default.
• W2074805281 hasConcept C2778198053 @default.
• W2074805281 hasConcept C2778988552 @default.
• W2074805281 hasConcept C2992204568 @default.
• W2074805281 hasConcept C71924100 @default.
• W2074805281 hasConceptScore W2074805281C126322002 @default.
• W2074805281 hasConceptScore W2074805281C134018914 @default.
• W2074805281 hasConceptScore W2074805281C170493617 @default.
• W2074805281 hasConceptScore W2074805281C185592680 @default.
• W2074805281 hasConceptScore W2074805281C2775846464 @default.
• W2074805281 hasConceptScore W2074805281C2775915353 @default.
• W2074805281 hasConceptScore W2074805281C2776741303 @default.
• W2074805281 hasConceptScore W2074805281C2777819096 @default.
• W2074805281 hasConceptScore W2074805281C2777960253 @default.
• W2074805281 hasConceptScore W2074805281C2778069365 @default.
• W2074805281 hasConceptScore W2074805281C2778198053 @default.
• W2074805281 hasConceptScore W2074805281C2778988552 @default.
• W2074805281 hasConceptScore W2074805281C2992204568 @default.
• W2074805281 hasConceptScore W2074805281C71924100 @default.
• W2074805281 hasLocation W20748052811 @default.
• W2074805281 hasLocation W20748052812 @default.
• W2074805281 hasOpenAccess W2074805281 @default.
• W2074805281 hasPrimaryLocation W20748052811 @default.
• W2074805281 hasRelatedWork W1620469576 @default.
• W2074805281 hasRelatedWork W178130271 @default.
• W2074805281 hasRelatedWork W1989621039 @default.
• W2074805281 hasRelatedWork W2008775909 @default.
• W2074805281 hasRelatedWork W2017740642 @default.
• W2074805281 hasRelatedWork W2021227270 @default.
• W2074805281 hasRelatedWork W2023188753 @default.
• W2074805281 hasRelatedWork W2033917368 @default.
• W2074805281 hasRelatedWork W2033948632 @default.
• W2074805281 hasRelatedWork W2041077595 @default.
• W2074805281 hasRelatedWork W2054715212 @default.
• W2074805281 hasRelatedWork W2086206863 @default.
• W2074805281 hasRelatedWork W2095304387 @default.
• W2074805281 hasRelatedWork W2096390902 @default.
• W2074805281 hasRelatedWork W2110765038 @default.
• W2074805281 hasRelatedWork W2126747284 @default.
• W2074805281 hasRelatedWork W2148223752 @default.
• W2074805281 hasRelatedWork W2229847901 @default.
• W2074805281 hasRelatedWork W1990348648 @default.

• next