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• W2074810859 abstract "Here in, we report the design, synthesis, and antibacterial activity of series of bulky arenesulfonamido derivatives using ciprofloxacin and norfloxacin as scaffolds. All the synthesized compounds were investigated in vitro for their antibacterial activities against two Gram-positive and two Gram-negative organisms using dilution broth method. Among the tested compounds examined, compounds 3-7 showed significance difference from the standard drug ciprofloxacin. 2D-QSAR study provides details on the fine relationship linking structure and activity and offers clues for structural modifications that can improve the activity. Docking study of the compound 3b into the active site of the topoisomerase II DNA-gyrase enzymes revealed a similar binding mode to ciprofloxacin with additional classical and nonclassical hydrogen bonds." @default.
• W2074810859 created "2016-06-24" @default.
• W2074810859 creator A5018002037 @default.
• W2074810859 creator A5082523652 @default.
• W2074810859 creator A5087698988 @default.
• W2074810859 date "2011-11-01" @default.
• W2074810859 modified "2023-10-05" @default.
• W2074810859 title "Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study" @default.
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• W2074810859 doi "https://doi.org/10.1016/j.ejmech.2011.09.011" @default.
• W2074810859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21982337" @default.
• W2074810859 hasPublicationYear "2011" @default.
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