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- W2074821253 endingPage "72" @default.
- W2074821253 startingPage "62" @default.
- W2074821253 abstract "Balancing mitophagy and mitochondrial biogenesis is essential for maintaining a healthy population of mitochondria and cellular homeostasis. Coordinated interplay between these two forces that govern mitochondrial turnover plays an important role as an adaptive response against various cellular stresses that can compromise cell survival. Failure to maintain the critical balance between mitophagy and mitochondrial biogenesis or homeostatic turnover of mitochondria results in a population of dysfunctional mitochondria that contribute to various disease processes. In this review we outline the mechanics and relationships between mitophagy and mitochondrial biogenesis, and discuss the implications of a disrupted balance between these two forces, with an emphasis on cardiac physiology. This article is part of a Special Issue entitled Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease." @default.
- W2074821253 created "2016-06-24" @default.
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- W2074821253 creator A5063586748 @default.
- W2074821253 creator A5064754084 @default.
- W2074821253 date "2015-01-01" @default.
- W2074821253 modified "2023-10-17" @default.
- W2074821253 title "A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology" @default.
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